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Literature summary for 1.14.19.41 extracted from

  • Sun, X.; Wang, W.; Wang, K.; Yu, X.; Liu, J.; Zhou, F.; Xie, B.; Li, S.
    Sterol C-22 desaturase ERG5 mediates the sensitivity to antifungal azoles in Neurospora crassa and Fusarium verticillioides (2013), Front. Microbiol., 4, 127.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.19.41

Inhibitors

Inhibitors Comment Organism Structure
fluconazole
-
 Fusarium verticillioides
fluconazole
-
 Neurospora crassa
itraconazole
-
 Fusarium verticillioides
itraconazole
-
 Neurospora crassa
ketoconazole
-
 Fusarium verticillioides
ketoconazole
-
 Neurospora crassa

Organism

Organism UniProt Comment Textmining
Fusarium verticillioides
-
-
-
Neurospora crassa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ergosta-5,7-dien-3beta-ol + NADPH + H+ + O2
-
 Neurospora crassa ergosterol + NADP+ + H2O
-
 ?
ergosta-5,7-dien-3beta-ol + NADPH + H+ + O2
-
 Fusarium verticillioides ergosterol + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
ERG5
-
 Neurospora crassa
ERG5
-
 Fusarium verticillioides
sterol C-22 desaturase
-
 Neurospora crassa
sterol C-22 desaturase
-
 Fusarium verticillioides

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Neurospora crassa
NADPH
-
 Fusarium verticillioides

General Information

General Information Comment Organism
malfunction enzyme gene erg5 deletion increases azole susceptibility but does not cause accumulation of 14alpha-methylated sterols during ketoconazole stress in Neurospora crassa Neurospora crassa