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Literature summary for 1.14.19.30 extracted from

  • Irazu, C.; Gonzalez-Rodriguez, S.; Brenner, R.
    DELTA5 Desaturase activity in rat kidney microsomes (1993), Mol. Cell. Biochem., 129, 31-37.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] the DELTA5 desaturase activity in kidney microsomes increases linearly with the substrate concentration up to 0.02 mM Rattus norvegicus
additional information neither the cytosolic renal fraction nor the cytosolic liver fraction enhance the DELTA5 desaturase activity Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.056
-
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] at pH 7.0 and 36°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ Rattus norvegicus
-
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
-
Rattus norvegicus (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O
-
?

Synonyms

Synonyms Comment Organism
DELTA5 desaturase
-
Rattus norvegicus
DES5
-
Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Rattus norvegicus
CoA dependent on Rattus norvegicus
cytochrome b5 dependent on Rattus norvegicus
NADH dependent on Rattus norvegicus