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Literature summary for 1.14.19.20 extracted from

  • Chau, A.; Gurnani, M.; Hawkinson, R.; Laverdiere, M.; Cacciapuoti, A.; McNicholas, P.
    Inactivation of sterol DELTA5,6-desaturase attenuates virulence in Candida albicans (2005), Antimicrob. Agents Chemother., 49, 3646-3651.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Candida albicans O93875 isolates C43, C655, C673, and C410
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
14-methylfecosterol + ferrocytochrome b5 + O2 + H+
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Candida albicans 14-methylergosta-5,8,24(28)-trien-3beta-ol + ferricytochrome b5 + H2O
-
?
ergosta-7,22-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
-
Candida albicans ergosterol + ferricytochrome b5 + 2 H2O
-
?

Synonyms

Synonyms Comment Organism
Erg3p
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Candida albicans
sterol DELTA5,6-desaturase
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Candida albicans

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
Candida albicans

General Information

General Information Comment Organism
malfunction inactivation of sterol DELTA5,6-desaturase attenuates virulence in Candida albicans Candida albicans
metabolism the enzyme is involved in ergosterol synthesis Candida albicans