Literature summary for 1.14.19.17 extracted from

Causeret, C.; Geeraert, L.; Van der Hoeven, G.; Mannaerts, G.; Van Veldhoven, P.
Further characterization of rat dihydroceramide desaturase: Tissue distribution, subcellular localization, and substrate specificity (2000), Lipids, 35, 1117-1125.

Search for more literature for 1.14.19.17

Activating Compound

Activating Compound	Comment	Organism	Structure
albumin	-	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-cyclodextrin	18% residual activity at a substrate/cyclodextrin molar ratio of 0.5	Rattus norvegicus
beta-cyclodextrin	20% residual activity at a substrate/cyclodextrin molar ratio of 0.5	Rattus norvegicus
Brij-35	13% residual activity at 0.1 mM	Rattus norvegicus
CHAPS	3.0% residual activity at 6.5 mM	Rattus norvegicus
decylmaltoside	27% residual activity at 1.6 mM	Rattus norvegicus
lauryl-N,N-dimethylamine	28% residual activity at 2.1 mM	Rattus norvegicus
N-dodecylsarcosine	complete inhibition at 14.6 mM	Rattus norvegicus
N-octyl-N,N-dimethyl-3-ammonio-1-propane sulfonate	18% residual activity at 330 mM	Rattus norvegicus
octylglucoside	8.5% residual activity at 25 mM	Rattus norvegicus
SDS	0.3% residual activity at 0.24% (w/v)	Rattus norvegicus
sucrose monolaurate	27% residual activity at 0.2 mM	Rattus norvegicus
Thesit	23% residual activity at 0.1 mM	Rattus norvegicus
Triton X-100	13% residual activity at 0.25 mM	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	-	Rattus norvegicus	5783	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
dihydroceramide + ferrocytochrome b5 + O2 + H+	Rattus norvegicus	-	(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q564G3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
harderian gland	-	Rattus norvegicus	-
hepatocyte	-	Rattus norvegicus	-
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dihydroceramide + ferrocytochrome b5 + O2 + H+	-	Rattus norvegicus	(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O	-	?
N-hexanoyl-[4,5-3H]sphinganine + NADPH + O2 + H+	-	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
DHCD	-	Rattus norvegicus
dihydroceramide desaturase	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome b5	-	Rattus norvegicus
NADH	dependent on, higher activity with NADPH compared to NADH	Rattus norvegicus
NADPH	dependent on, higher activity with NADPH compared to NADH	Rattus norvegicus

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Release 2023.1 (January 2023)