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Literature summary for 1.14.19.1 extracted from

  • Nashed, M.; Chisholm, J.W.; Igal, R.A.
    Stearoyl-CoA desaturase activity modulates the activation of epidermal growth factor receptor in human lung cancer cells (2012), Exp. Biol. Med. (Maywood), 237, 1007-1017.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
CVT-11127 specific small molecule inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
stearoyl-CoA + ferrocytochrome b5 + O2 + H+ Homo sapiens
-
oleoyl-CoA + ferricytochrome b5 + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
lung cancer cell
-
Homo sapiens
-
NCI-H1299 cell
-
Homo sapiens
-
NCI-H460 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
-
Homo sapiens oleoyl-CoA + ferricytochrome b5 + H2O
-
?

Synonyms

Synonyms Comment Organism
DELTA9 desaturase
-
Homo sapiens
SCD1
-
Homo sapiens
stearoyl-CoA desaturase-1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ferrocytochrome b5
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme level is increased in human lung tumors up

General Information

General Information Comment Organism
malfunction the ablation of enzyme activity has an immediate and profound impact on the fatty acid content of cell lipids. Enzyme inhibition alters the epidermal growth factor-dependent signaling mechanism, decreases the mobility of fluid domains in plasma membranes, and reduces EGF-induced proliferation in lung cancer cells Homo sapiens
physiological function the enzyme activity is the most critical determinant of the monounsaturated/saturated fatty acid balance in cancer cells Homo sapiens