Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CVT-11127 | specific small molecule inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | Homo sapiens | - |
oleoyl-CoA + ferricytochrome b5 + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
lung cancer cell | - |
Homo sapiens | - |
NCI-H1299 cell | - |
Homo sapiens | - |
NCI-H460 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | - |
Homo sapiens | oleoyl-CoA + ferricytochrome b5 + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DELTA9 desaturase | - |
Homo sapiens |
SCD1 | - |
Homo sapiens |
stearoyl-CoA desaturase-1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ferrocytochrome b5 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme level is increased in human lung tumors | up |
General Information | Comment | Organism |
---|---|---|
malfunction | the ablation of enzyme activity has an immediate and profound impact on the fatty acid content of cell lipids. Enzyme inhibition alters the epidermal growth factor-dependent signaling mechanism, decreases the mobility of fluid domains in plasma membranes, and reduces EGF-induced proliferation in lung cancer cells | Homo sapiens |
physiological function | the enzyme activity is the most critical determinant of the monounsaturated/saturated fatty acid balance in cancer cells | Homo sapiens |