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Literature summary for 1.14.19.1 extracted from
- 2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors (2010), Bioorg. Med. Chem. Lett., 20, 6366-6369.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-(2'-chlorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | - |
Homo sapiens |  |
| 2-(2'-chlorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 2-(2'-fluorobiphenyl-4-yl)-1-methyl-5-(methylsulfonyl)-2,3-dihydro-1H-benzimidazole | - |
Rattus norvegicus | |
| 2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole-6-sulfonamide | - |
Homo sapiens | |
| 2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole-6-sulfonamide | - |
Rattus norvegicus | |
| 2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfanyl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfinyl)-1H-benzimidazole | - |
Homo sapiens | |
| 2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfinyl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | - |
Homo sapiens | |
| 2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-imidazo[4,5-b]pyridine | - |
Homo sapiens | |
| 2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-imidazo[4,5-b]pyridine | - |
Rattus norvegicus | |
| 2-(2'-fluorobiphenyl-4-yl)-N,N-dimethyl-1H-benzimidazole-6-sulfonamide | - |
Rattus norvegicus | |
| 2-(2'-methylbiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 2-(3'-chloro-2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 2-(3'-chlorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | - |
Homo sapiens | |
| 2-(3'-chlorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 2-(3'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | - |
Homo sapiens | |
| 2-(3'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 2-(3'-methylbiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 2-(4'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 2-(5'-chloro-2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 2-(biphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | - |
Homo sapiens | |
| 2-(biphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 2-(biphenyl-4-yl)-7-(methylsulfonyl)imidazo[1,2-a]pyridine | - |
Homo sapiens | |
| 2-(biphenyl-4-yl)-7-(methylsulfonyl)imidazo[1,2-a]pyridine | - |
Rattus norvegicus | |
| 2-[4-(furan-3-yl)phenyl]-6-(methylsulfonyl)-1H-benzimidazole | - |
Homo sapiens | |
| 2-[4-(furan-3-yl)phenyl]-6-(methylsulfonyl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 2-[5-(2-fluorophenyl)pyridin-2-yl]-6-(methylsulfonyl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 2-[6-(2-fluorophenyl)pyridin-3-yl]-6-(methylsulfonyl)-1H-benzimidazole | - |
Homo sapiens | |
| 2-[6-(2-fluorophenyl)pyridin-3-yl]-6-(methylsulfonyl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 4'-[6-(methylsulfonyl)-1H-benzimidazol-2-yl]biphenyl-2-ol | - |
Rattus norvegicus | |
| 4'-[6-(methylsulfonyl)-1H-benzimidazol-2-yl]biphenyl-3-ol | - |
Homo sapiens | |
| 4'-[6-(methylsulfonyl)-1H-benzimidazol-2-yl]biphenyl-3-ol | - |
Rattus norvegicus | |
| 4'-[6-(methylsulfonyl)-1H-benzimidazol-2-yl]biphenyl-4-ol | - |
Homo sapiens | |
| 4'-[6-(methylsulfonyl)-1H-benzimidazol-2-yl]biphenyl-4-ol | - |
Rattus norvegicus | |
| 6-(cyclopropylsulfonyl)-2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 6-(ethylsulfonyl)-2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole | - |
Homo sapiens | |
| 6-(ethylsulfonyl)-2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 6-(methylsulfonyl)-2-(2-phenylpyrimidin-5-yl)-1H-benzimidazole | - |
Rattus norvegicus | |
| 6-(methylsulfonyl)-2-[4-(3-methylthiophen-2-yl)phenyl]-1H-benzimidazole | - |
Rattus norvegicus | |
| 6-(methylsulfonyl)-2-[4-(pyridin-2-yl)phenyl]-1H-benzimidazole | - |
Homo sapiens | |
| 6-(methylsulfonyl)-2-[4-(pyridin-2-yl)phenyl]-1H-benzimidazole | - |
Rattus norvegicus | |
| 6-(methylsulfonyl)-2-[4-(pyridin-3-yl)phenyl]-1H-benzimidazole | - |
Rattus norvegicus | |
| 6-(methylsulfonyl)-2-[4-(pyridin-4-yl)phenyl]-1H-benzimidazole | - |
Homo sapiens | |
| 6-(methylsulfonyl)-2-[4-(pyridin-4-yl)phenyl]-1H-benzimidazole | - |
Rattus norvegicus | |
| 6-(methylsulfonyl)-2-[4-(thiophen-2-yl)phenyl]-1H-benzimidazole | - |
Homo sapiens | |
| 6-(methylsulfonyl)-2-[4-(thiophen-2-yl)phenyl]-1H-benzimidazole | - |
Rattus norvegicus | |
| 6-(methylsulfonyl)-2-[4-(thiophen-3-yl)phenyl]-1H-benzimidazole | - |
Rattus norvegicus | |
| 6-tert-butyl-2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole | - |
Homo sapiens | |
| 6-tert-butyl-2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | - |
Homo sapiens | |
| Fe2+ | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| stearoyl coenzyme-A desaturase 1 | - |
Homo sapiens |
| stearoyl coenzyme-A desaturase 1 | - |
Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000015 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(3'-chlorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.000019 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[6-(2-fluorophenyl)pyridin-3-yl]-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.00002 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(biphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.000021 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(3'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.000024 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(biphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.000025 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(4'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.000027 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.00003 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(3'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.000042 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(biphenyl-4-yl)-7-(methylsulfonyl)imidazo[1,2-a]pyridine | |
| 0.000058 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-[6-(2-fluorophenyl)pyridin-3-yl]-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.00006 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(biphenyl-4-yl)-7-(methylsulfonyl)imidazo[1,2-a]pyridine | |
| 0.000065 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.000074 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole-6-sulfonamide | |
| 0.000095 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(3'-chloro-2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.000096 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfinyl)-1H-benzimidazole | |
| 0.000097 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 6-(methylsulfonyl)-2-[4-(thiophen-2-yl)phenyl]-1H-benzimidazole | |
| 0.000104 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 6-(methylsulfonyl)-2-[4-(thiophen-3-yl)phenyl]-1H-benzimidazole | |
| 0.000113 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-imidazo[4,5-b]pyridine | |
| 0.000148 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(3'-chlorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.000156 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-imidazo[4,5-b]pyridine | |
| 0.000175 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 6-tert-butyl-2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole | |
| 0.000227 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-[5-(2-fluorophenyl)pyridin-2-yl]-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.000231 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 6-(methylsulfonyl)-2-[4-(thiophen-2-yl)phenyl]-1H-benzimidazole | |
| 0.000255 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(2'-chlorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.000278 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(5'-chloro-2'-fluorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.000304 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4'-[6-(methylsulfonyl)-1H-benzimidazol-2-yl]biphenyl-4-ol | |
| 0.000319 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(3'-methylbiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.000336 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4'-[6-(methylsulfonyl)-1H-benzimidazol-2-yl]biphenyl-2-ol | |
| 0.000342 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4'-[6-(methylsulfonyl)-1H-benzimidazol-2-yl]biphenyl-3-ol | |
| 0.000343 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole-6-sulfonamide | |
| 0.000395 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-[4-(furan-3-yl)phenyl]-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.000396 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4'-[6-(methylsulfonyl)-1H-benzimidazol-2-yl]biphenyl-3-ol | |
| 0.000401 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 6-(cyclopropylsulfonyl)-2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole | |
| 0.000425 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 6-(methylsulfonyl)-2-[4-(pyridin-3-yl)phenyl]-1H-benzimidazole | |
| 0.000472 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfinyl)-1H-benzimidazole | |
| 0.000472 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 6-(methylsulfonyl)-2-[4-(3-methylthiophen-2-yl)phenyl]-1H-benzimidazole | |
| 0.000489 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 6-(methylsulfonyl)-2-(2-phenylpyrimidin-5-yl)-1H-benzimidazole | |
| 0.000528 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(2'-fluorobiphenyl-4-yl)-N,N-dimethyl-1H-benzimidazole-6-sulfonamide | |
| 0.000697 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(2'-fluorobiphenyl-4-yl)-6-(methylsulfanyl)-1H-benzimidazole | |
| 0.000731 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 6-tert-butyl-2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole | |
| 0.001248 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 6-(ethylsulfonyl)-2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole | |
| 0.001308 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 6-(ethylsulfonyl)-2-(2'-fluorobiphenyl-4-yl)-1H-benzimidazole | |
| 0.001705 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[4-(furan-3-yl)phenyl]-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.001713 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 6-(methylsulfonyl)-2-[4-(pyridin-2-yl)phenyl]-1H-benzimidazole | |
| 0.00176 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 6-(methylsulfonyl)-2-[4-(pyridin-2-yl)phenyl]-1H-benzimidazole | |
| 0.002326 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4'-[6-(methylsulfonyl)-1H-benzimidazol-2-yl]biphenyl-4-ol | |
| 0.002473 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 6-(methylsulfonyl)-2-[4-(pyridin-4-yl)phenyl]-1H-benzimidazole | |
| 0.002488 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(2'-fluorobiphenyl-4-yl)-1-methyl-5-(methylsulfonyl)-2,3-dihydro-1H-benzimidazole | |
| 0.003863 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(2'-methylbiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | |
| 0.004246 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 6-(methylsulfonyl)-2-[4-(pyridin-4-yl)phenyl]-1H-benzimidazole | |
| 0.004489 | - |
pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 2-(2'-chlorobiphenyl-4-yl)-6-(methylsulfonyl)-1H-benzimidazole | |
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