Literature summary for 1.14.19.1 extracted from

Toyama, T.; Kudo, N.; Mitsumoto, A.; Hibino, Y.; Tsuda, T.; Kawashima, Y.
Stearoyl-CoA desaturase activity is elevated by the suppression of its degradation by clofibric acid in the liver of rats (2007), J. Pharmacol. Sci., 103, 383-390.

Search for more literature for 1.14.19.1

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	treatment of rats with 2-(4-chlorophenoxy)-2-methylpropionic acid, i.e. clofibric acid, or feeding of a fat-free diet markedly elevated hepatic activity of SCD by increasing the steady-state level of SCD1 mRNA and enhancing transcriptional rate, metabolic effects, overview	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
SCD1, realtime-PCR-based quantitative expression analysis	Rattus norvegicus
SCD2, realtime-PCR-based quantitative expression analysis	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Rattus norvegicus	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	decreased degradation of SCD is responsible for the increase in palmitoyl-CoA chain elongase activity in addition to increased transcription of SCD1 in the rats treated with clofibric acid, overview	?	-	?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+	Rattus norvegicus	-	oleoyl-CoA + ferricytochrome b5 + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P07308	SCD1	-
Rattus norvegicus	Q6P7B9	SCD2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	decreased degradation of SCD is responsible for the increase in palmitoyl-CoA chain elongase activity in addition to increased transcription of SCD1 in the rats treated with clofibric acid, overview	Rattus norvegicus	?	-	?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+	-	Rattus norvegicus	oleoyl-CoA + ferricytochrome b5 + H2O	-	?

Synonyms

Synonyms	Comment	Organism
SCD	-	Rattus norvegicus
SCD2	-	Rattus norvegicus
stearoyl-CoA desaturase	-	Rattus norvegicus
stearoyl-CoA desaturase 2	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ferrocytochrome b5	-	Rattus norvegicus

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Release 2023.1 (January 2023)