Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CGX0168 | - |
Homo sapiens | |
CGX0290 | - |
Homo sapiens | |
trans-10,cis-12 conjugated linoleic acid | inhibits stearate desaturation only, not that of palmitate | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | role of SCD1 in fatty acid metabolism in HepG2 cells, the desaturation systems in Hep-G2 cells are strongly compartmentalized, effects of SCD1 inhibition on fatty acid composition in HepG2 cells occur through changes in the dynamics of the fatty acid metabolic network and not through transcriptional regulatory mechanisms, overview | ? | - |
? | |
palmitoyl-CoA + ferrocytochrome b5 + O2 + 2 H+ | Homo sapiens | a key step in triglyceride synthesis in the fatty acid metabolic network | palmitoleoyl-CoA + ferricytochrome b5 + 2 H2O | - |
? | |
stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | Homo sapiens | a key step in triglyceride synthesis in the fatty acid metabolic network | oleoyl-CoA + ferricytochrome b5 + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
fatty acid compositions in presence and absence of inhibitors | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | role of SCD1 in fatty acid metabolism in HepG2 cells, the desaturation systems in Hep-G2 cells are strongly compartmentalized, effects of SCD1 inhibition on fatty acid composition in HepG2 cells occur through changes in the dynamics of the fatty acid metabolic network and not through transcriptional regulatory mechanisms, overview | Homo sapiens | ? | - |
? | |
palmitoyl-CoA + ferrocytochrome b5 + O2 + 2 H+ | - |
Homo sapiens | palmitoleoyl-CoA + ferricytochrome b5 + 2 H2O | - |
? | |
palmitoyl-CoA + ferrocytochrome b5 + O2 + 2 H+ | a key step in triglyceride synthesis in the fatty acid metabolic network | Homo sapiens | palmitoleoyl-CoA + ferricytochrome b5 + 2 H2O | - |
? | |
stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | - |
Homo sapiens | oleoyl-CoA + ferricytochrome b5 + H2O | - |
? | |
stearoyl-CoA + ferrocytochrome b5 + O2 + H+ | a key step in triglyceride synthesis in the fatty acid metabolic network | Homo sapiens | oleoyl-CoA + ferricytochrome b5 + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SCD1 | - |
Homo sapiens |
stearoyl-CoA desaturase enzyme-1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ferrocytochrome b5 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00058 | - |
cell assay | Homo sapiens | CGX0290 | |
0.00152 | - |
biochemical assay | Homo sapiens | CGX0290 | |
0.00172 | - |
biochemical assay | Homo sapiens | CGX0168 | |
0.00187 | - |
cell assay | Homo sapiens | CGX0168 |