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Literature summary for 1.14.18.6 extracted from

  • Uchida, Y.; Hama, H.; Alderson, N.L.; Douangpanya, S.; Wang, Y.; Crumrine, D.A.; Elias, P.M.; Holleran, W.M.
    Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation (2007), J. Biol. Chem., 282, 13211-13219.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens Q7L5A8
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Source Tissue

Source Tissue Comment Organism Textmining
epidermis FA2H is expressed in cultured human keratinocytes and human epidermis, with FA2H expression and fatty acid 2-hydroxylase activity increasing with differentiation Homo sapiens
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keratinocyte FA2H is expressed in cultured human keratinocytes and human epidermis, with FA2H expression and fatty acid 2-hydroxylase activity increasing with differentiation Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information 2-hydroxylation of fatty acid by FA2H occurs prior to generation of ceramides/glucosylceramides. FA2H expression and 2-hydroxy-free fatty acid production increase early in keratinocyte differentiation, production of 2-hydroxyceramides/2-hydroxyglucosylceramides with longer chain amide-linked fatty acids (more than C24) increases later Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
FA2H
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens differentiation-dependent up-regulation of ceramide synthesis and fatty acid elongation is accompanied by up-regulation of FA2H up

General Information

General Information Comment Organism
physiological function FA2H-siRNA suppresses 2-hydroxylase activity and decreases 2-hydroxyceramide/2-hydroxyglucosylceramide levels. Keratinocytes transduced with FA2H-siRNA contain abnormal epidermal lamellar bodies and do not form the normal extracellular lamellar membranes required for the epidermal permeability barrier Homo sapiens