Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone | dalenin, the reversible inhibitor is 52 and 495times more effective as a monophenolase inhibitor than hydroquinone and kojic acid, respectively, non-competitive inhibitor with L-DOPA as substrate, mixed-I type inhibitor with L-tyrosine as substrate | Agaricus bisporus | |
hydroquinone | - |
Agaricus bisporus | |
kojic acid | - |
Agaricus bisporus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.347 | - |
L-tyrosine | in 50 mM phosphate buffer, pH 6.5, at 37°C | Agaricus bisporus | |
1.44 | - |
L-Dopa | in 50 mM phosphate buffer, pH 6.5, at 37°C | Agaricus bisporus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-DOPA + O2 | monophenolase activity | Agaricus bisporus | dopaquinone + H2O | - |
? | |
L-tyrosine + O2 | diphenolase activity | Agaricus bisporus | L-DOPA + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosinase | - |
Agaricus bisporus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00198 | - |
5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone | value for inhibition of diphenolase activity using L-tyrosine as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C | Agaricus bisporus | |
0.16 | - |
5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone | value for inhibition of monophenolase activity using L-Dopa as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C | Agaricus bisporus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00026 | - |
value for inhibition of diphenolase activity using L-tyrosine as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C | Agaricus bisporus | 5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone | |
0.01348 | - |
value for inhibition of diphenolase activity using L-tyrosine as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C | Agaricus bisporus | hydroquinone | |
0.01857 | - |
value for inhibition of monophenolase activity using L-Dopa as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C | Agaricus bisporus | kojic acid | |
0.01861 | - |
value for inhibition of monophenolase activity using L-Dopa as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C | Agaricus bisporus | 5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone | |
0.129 | - |
value for inhibition of diphenolase activity using L-tyrosine as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C | Agaricus bisporus | kojic acid | |
1.09 | - |
value for inhibition of monophenolase activity using L-Dopa as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C | Agaricus bisporus | hydroquinone |