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Literature summary for 1.14.18.1 extracted from

  • Marino, S.M.; Fogal, S.; Bisaglia, M.; Moro, S.; Scartabelli, G.; De Gioia, L.; Spada, A.; Monzani, E.; Casella, L.; Mammi, S.; Bubacco, L.
    Investigation of Streptomyces antibioticus tyrosinase reactivity toward chlorophenols (2011), Arch. Biochem. Biophys., 505, 67-74.
    View publication on PubMed
Search for more literature for 1.14.18.1

Inhibitors

Inhibitors Comment Organism Structure
2-chlorophenol competitive inhibitor Streptomyces antibioticus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.35
-
 4-Chlorophenol in 100 mM phosphate buffer, pH 6.8, at 25°C Streptomyces antibioticus
11
-
 3-chlorophenol in 100 mM phosphate buffer, pH 6.8, at 25°C Streptomyces antibioticus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ contains copper Streptomyces antibioticus

Organism

Organism UniProt Comment Textmining
Streptomyces antibioticus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-chlorophenol + O2 20% of 3-chlorophenol is oxidized after 2 h by tyrosinase Streptomyces antibioticus 4-chloro-1,2-quinone + H2O 4-chloro-1,2-quinone subsequently undergoes a nucleophilic substitution reaction at the chlorine atom by excess phenol to give the corresponding phenol-quinone adduct 4-(3-chlorophenoxy)cyclohexa-3,5-diene-1,2-dione ?
4-chlorophenol + O2 91% of 4-chlorophenol is oxidized after 2 h by tyrosinase Streptomyces antibioticus 4-chloro-1,2-quinone + H2O 4-chloro-1,2-quinone subsequently undergoes a nucleophilic substitution reaction at the chlorine atom by excess phenol to give the corresponding phenol-quinone adduct 4-(4-chlorophenoxy)cyclohexa-3,5-diene-1,2-dione ?
L-DOPA + O2
-
 Streptomyces antibioticus dopaquinone + H2O
-
 ?
additional information 2-chlorophenol is not reactive with tyrosinase Streptomyces antibioticus ?
-
 ?

Synonyms

Synonyms Comment Organism
tyrosinase
-
 Streptomyces antibioticus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.9
-
 3-chlorophenol in 100 mM phosphate buffer, pH 6.8, at 25°C Streptomyces antibioticus
5.6
-
 4-Chlorophenol in 100 mM phosphate buffer, pH 6.8, at 25°C Streptomyces antibioticus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
7.5
-
 2-chlorophenol in 100 mM phosphate buffer, pH 6.8, at 25°C Streptomyces antibioticus