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Literature summary for 1.14.18.1 extracted from

  • Guo, Y.J.; Pan, Z.Z.; Chen, C.Q.; Hu, Y.H.; Liu, F.J.; Shi, Y.; Yan, J.H.; Chen, Q.X.
    Inhibitory effects of fatty acids on the activity of mushroom tyrosinase (2010), Appl. Biochem. Biotechnol., 162, 1564-1573.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2E)-but-2-enoic acid non-competitive inhibition Agaricus bisporus
(2E,4E)-hexa-2,4-dienoic acid non-competitive inhibition Agaricus bisporus
4-chlorosalicylic acid
-
Agaricus bisporus
alpha-cyano-4-hydroxycinnamic acid
-
Agaricus bisporus
azelaic acid
-
Agaricus bisporus
cefazolin
-
Agaricus bisporus
cefodizime
-
Agaricus bisporus
hexanoic acid mixed-type inhibition Agaricus bisporus
kojic acid
-
Agaricus bisporus
additional information not inhibited by butyric acid Agaricus bisporus
octanoic acid mixed-type inhibition Agaricus bisporus
phloridzin dihydrate
-
Agaricus bisporus
tropolone
-
Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-DOPA + O2 monophenolase activity Agaricus bisporus dopaquinone + H2O
-
?
L-Tyr + O2 diphenolase activity Agaricus bisporus L-Dopa + H2O
-
?

Synonyms

Synonyms Comment Organism
tyrosinase
-
Agaricus bisporus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.91
-
(2E,4E)-hexa-2,4-dienoic acid in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus
1.54
-
octanoic acid in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus
2.51
-
hexanoic acid in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus
12
-
(2E)-but-2-enoic acid in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.9
-
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus (2E,4E)-hexa-2,4-dienoic acid
2.15
-
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus octanoic acid
3.06
-
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus octanoic acid
3.35
-
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus hexanoic acid
4.95
-
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus (2E,4E)-hexa-2,4-dienoic acid
12.05
-
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus (2E)-but-2-enoic acid
13.2
-
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus hexanoic acid
20
-
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C Agaricus bisporus (2E)-but-2-enoic acid

General Information

General Information Comment Organism
physiological function tyrosinase is a key enzyme in the melanin biosynthesis Agaricus bisporus