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Literature summary for 1.14.18.1 extracted from

  • Bandyopadhyay, P.; Jha, S.; Imran Ali, S.K.
    Picolyl alkyl amines as novel tyrosinase inhibitors: Influence of hydrophobicity and substitution (2009), J. Agric. Food Chem., 57, 9780-9786.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alpha-picolyl heptyl amine
-
Agaricus bisporus
alpha-picolyl nonyl amine
-
Agaricus bisporus
alpha-picolyl pentyl amine
-
Agaricus bisporus
alpha-picolyl propyl amine
-
Agaricus bisporus
beta-picolyl heptyl amine uncompetitive inhibition of monophenolase and diphenolase activities Agaricus bisporus
beta-picolyl nonyl amine
-
Agaricus bisporus
beta-picolyl pentyl amine uncompetitive inhibition of monophenolase and diphenolase activities Agaricus bisporus
beta-picolyl propyl amine uncompetitive inhibition of monophenolase and diphenolase activities Agaricus bisporus
gamma-picolyl heptyl amine uncompetitive inhibition of monophenolase activity and mixed-type inhibition of diphenolase activity Agaricus bisporus
gamma-picolyl nonyl amine
-
Agaricus bisporus
gamma-picolyl pentyl amine uncompetitive inhibition of monophenolase activity and mixed-type inhibition of diphenolase activity Agaricus bisporus
gamma-picolyl propyl amine uncompetitive inhibition of monophenolase activity and mixed-type inhibition of diphenolase activity Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-DOPA + O2 o-diphenolase activity Agaricus bisporus dopaquinone + H2O
-
?
L-tyrosine + O2 o-monophenolase activity Agaricus bisporus L-DOPA + H2O
-
?

Synonyms

Synonyms Comment Organism
tyrosinase
-
Agaricus bisporus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
18
-
gamma-picolyl heptyl amine in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus
20
-
gamma-picolyl pentyl amine in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus
23
-
gamma-picolyl propyl amine in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.2
-
in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus gamma-picolyl pentyl amine
5.8
-
in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus gamma-picolyl propyl amine
6.8
-
-
Agaricus bisporus gamma-picolyl heptyl amine
9.5
-
in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus beta-picolyl heptyl amine
12
-
IC50 above 12 mM, in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus alpha-picolyl propyl amine
12
-
IC50 above 12 mM, in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus alpha-picolyl pentyl amine
12
-
IC50 above 12 mM, in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus alpha-picolyl heptyl amine
12
-
in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus beta-picolyl propyl amine
12
-
in 0.1 M phosphate buffer (pH 6.5) Agaricus bisporus beta-picolyl pentyl amine