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Literature summary for 1.14.18.1 extracted from

  • Jeong, S.H.; Ryu, Y.B.; Curtis-Long, M.J.; Ryu, H.W.; Baek, Y.S.; Kang, J.E.; Lee, W.S.; Park, K.H.
    Tyrosinase inhibitory polyphenols from roots of Morus lhou (2009), J. Agric. Food Chem., 57, 1195-1203.
    View publication on PubMed
Search for more literature for 1.14.18.1

Inhibitors

Inhibitors Comment Organism Structure
8-isoprenyl-5'-geranyl-5,7,2',4'-tetrahydroxy flavanone competitive inhibitor Agaricus bisporus
albafuran A
-
 Agaricus bisporus
kojic acid
-
 Agaricus bisporus
kuwanon A
-
 Agaricus bisporus
kuwanon E competitive inhibitor Agaricus bisporus
kuwanon U
-
 Agaricus bisporus
moracin M competitive inhibitor Agaricus bisporus
moracin N competitive inhibitor Agaricus bisporus
moracinoside M competitive inhibitor Agaricus bisporus
morusinol
-
 Agaricus bisporus
neocyclomorusin competitive inhibitor Agaricus bisporus
norartocarpetin competitive inhibitor Agaricus bisporus
steppogenin competitive inhibitor Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-DOPA + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?
L-tyrosine + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?

Synonyms

Synonyms Comment Organism
polyphenoloxidase
-
 Agaricus bisporus
PPO
-
 Agaricus bisporus
tyrosinase
-
 Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0012
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus norartocarpetin
0.0013
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus steppogenin
0.0074
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus moracin M
0.0163
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kojic acid
0.0265
-
 using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus steppogenin
0.0442
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus 8-isoprenyl-5'-geranyl-5,7,2',4'-tetrahydroxy flavanone
0.0475
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kuwanon E
0.0646
-
 using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus moracin M
0.0825
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus moracinoside M
0.0985
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus albafuran A
0.1274
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus neocyclomorusin
0.1318
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kuwanon A
0.1603
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus moracin N
0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus norartocarpetin
0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kuwanon A
0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kuwanon E
0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kuwanon U
0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus 8-isoprenyl-5'-geranyl-5,7,2',4'-tetrahydroxy flavanone
0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus morusinol
0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus neocyclomorusin
0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus moracin N
0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus albafuran A
0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus moracinoside M
0.2
-
 IC50 above 0.2 mM, using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kuwanon U
0.2
-
 IC50 above 0.2 mM, using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus morusinol