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Literature summary for 1.14.18.1 extracted from

  • Yi, W.; Cao, R.H.; Chen, Z.Y.; Yu, L.; Ma, L.; Song, H.C.
    Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted phenylmethylenethiosemicarbazones as tyrosinase inhibitors (2009), Chem. Pharm. Bull., 57, 1273-1277.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-(2-furanylmethylene)-thiosemicarbazone
-
Agaricus bisporus
2-(phenylmethylene)-thiosemicarbazone
-
Agaricus bisporus
2-[(2,3,4-trihydroxyphenyl)methylene]-thiosemicarbazone
-
Agaricus bisporus
2-[(2,4-dihydroxyphenyl)methylene]-thiosemicarbazone most potent tyrosinase inhibitor Agaricus bisporus
2-[(2,5-dihydroxyphenyl)methylene]-thiosemicarbazone
-
Agaricus bisporus
2-[(2,5-dimethoxyphenyl)methylene]-thiosemicarbazone
-
Agaricus bisporus
2-[(2-hydroxy-4-bromophenyl)methylene]thiosemicarbazone
-
Agaricus bisporus
2-[(2-hydroxyphenyl)methylene]-thiosemicarbazone
-
Agaricus bisporus
2-[(3,4,5-trihydroxyphenyl)methylene]-thiosemicarbazone
-
Agaricus bisporus
2-[(3,4,5-trimethoxyphenyl)methylene]-thiosemicarbazone
-
Agaricus bisporus
2-[(3,4-dihydroxyphenyl)methylene]-thiosemicarbazone
-
Agaricus bisporus
2-[(3,5-dihydroxyphenyl)methylene]-thiosemicarbazone
-
Agaricus bisporus
2-[(3-hydroxy-4-methoxyphenyl)methylene]-thiosemicarbazone
-
Agaricus bisporus
2-[(3-hydroxyphenyl)methylene]-thiosemicarbazone
-
Agaricus bisporus
2-[(3-methoxy-4-hydroxyphenyl)methylene]-thiosemicarbazone
-
Agaricus bisporus
2-[(4-bromophenyl)methylene]-thiosemicarbazone
-
Agaricus bisporus
2-[(4-hydroxyphenyl)methylene]-thiosemicarbazone
-
Agaricus bisporus
2-[(4-methoxyphenyl)methylene]-thiosemicarbazone
-
Agaricus bisporus
4-hydroxybenzaldehyde
-
Agaricus bisporus
4-methoxycinnamic acid
-
Agaricus bisporus
Thiosemicarbazide
-
Agaricus bisporus
tropolone
-
Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Dopa + O2
-
Agaricus bisporus L-dopaquinone + H2O
-
?

Synonyms

Synonyms Comment Organism
polyphenol oxidase
-
Agaricus bisporus
PPO
-
Agaricus bisporus
tyrosinase
-
Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00018
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(2,4-dihydroxyphenyl)methylene]-thiosemicarbazone
0.00028
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(4-bromophenyl)methylene]-thiosemicarbazone
0.00033
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(2-hydroxy-4-bromophenyl)methylene]thiosemicarbazone
0.00038
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(2-hydroxyphenyl)methylene]-thiosemicarbazone
0.00041
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(4-hydroxyphenyl)methylene]-thiosemicarbazone
0.00042
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus tropolone
0.00045
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-(2-furanylmethylene)-thiosemicarbazone
0.00148
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(4-methoxyphenyl)methylene]-thiosemicarbazone
0.00193
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-(phenylmethylene)-thiosemicarbazone
0.0039
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(3-hydroxyphenyl)methylene]-thiosemicarbazone
0.00488
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(3-hydroxy-4-methoxyphenyl)methylene]-thiosemicarbazone
0.00568
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(3-methoxy-4-hydroxyphenyl)methylene]-thiosemicarbazone
0.0065
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(2,5-dihydroxyphenyl)methylene]-thiosemicarbazone
0.0336
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(3,5-dihydroxyphenyl)methylene]-thiosemicarbazone
0.0422
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(3,4-dihydroxyphenyl)methylene]-thiosemicarbazone
0.0875
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(2,5-dimethoxyphenyl)methylene]-thiosemicarbazone
0.1152
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(3,4,5-trihydroxyphenyl)methylene]-thiosemicarbazone
0.1455
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(3,4,5-trimethoxyphenyl)methylene]-thiosemicarbazone
0.2
-
IC50 above 0.2 mM, in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 2-[(2,3,4-trihydroxyphenyl)methylene]-thiosemicarbazone
0.41
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 4-methoxycinnamic acid
1.22
-
in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus 4-hydroxybenzaldehyde
2
-
IC50 aboe 2.0 mM, in 50 mM phosphate buffer (pH 6.8), at 25°C Agaricus bisporus Thiosemicarbazide