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Literature summary for 1.14.18.1 extracted from

  • Guan, S.; Su, W.; Wang, N.; Li, P.; Wang, Y.
    A potent tyrosinase activator from Radix Polygoni multiflori and its melanogenesis stimulatory effect in B16 melanoma cells (2008), Phytother. Res., 22, 660-663.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside THSG, tyrosinase activator isolated from Radix Polygoni multiflori Agaricus bisporus
2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside THSG, tyrosinase activator isolated from Radix Polygoni multiflori. It significantly increases the activity of murine tyrosinase and stimulates melanin biosynthesis in B16 melanoma cells. THSG is found to be non-cytotoxic to B16 melanoma cells at a concentration of 0.1-12.5 microg/ml Mus musculus
chrysophanol anthraquinone Mus musculus
chrysophanol anthraquinone, slightly activates tyrosinase Agaricus bisporus
emodin anthraquinone Mus musculus
emodin anthraquinone, slightly activates tyrosinase Agaricus bisporus
gallic acid
-
Mus musculus
gallic acid
-
Agaricus bisporus
physcion anthraquinone Mus musculus
physcion anthraquinone, slightly activates tyrosinase Agaricus bisporus

Application

Application Comment Organism
drug development activators of tyrosinase with stimulatory effects on melanogenesis are beneficial for the treatment of hypopigmentation diseases. 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside is a potent tyrosinase activator and stimulator of melanogenesis with potential for the treatment of hypopigmentation disease Mus musculus
drug development activators of tyrosinase with stimulatory effects on melanogenesis are beneficial for the treatment of hypopigmentation diseases. THSG is a potent tyrosinase activator and stimulator of melanogenesis with potential for the treatment of hypopigmentation disease Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-16 cell
-
Mus musculus
-
commercial preparation
-
Agaricus bisporus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
for the mushroom tyrosinase activity assay, mushroom tyrosinase with 100 U/ml is used Agaricus bisporus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-3,4-dihydroxyphenylalanine + 1/2 O2
-
Mus musculus L-dopaquinone + H2O
-
?
L-dopa + 1/2 O2
-
Agaricus bisporus L-dopachrome + H2O
-
?

Synonyms

Synonyms Comment Organism
murine tyrosinase from cultured B16 cells Mus musculus
tyrosinase
-
Mus musculus
tyrosinase
-
Agaricus bisporus