Literature summary for 1.14.18.1 extracted from

Ryu, Y.B.; Westwood, I.M.; Kang, N.S.; Kim, H.Y.; Kim, J.H.; Moon, Y.H.; Park, K.H.
Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens (2008), Phytomedicine, 15, 612-618.

Search for more literature for 1.14.18.1

Application

Application	Comment	Organism
drug development	kurarinol has the potential to be further developed as effective and safe anti-browning and skin-whitening agent	Agaricus bisporus

Inhibitors

Inhibitors	Comment	Organism	Structure
kurarinol	from the root of Sophora flavescens, shows no antibacterial activity, competitive inhibitor. Is 50times more potent than lavandulylated flavanones sophoraflavanone G and kurarinone	Agaricus bisporus
kurarinone	from the root of Sophora flavescens, exhibits potent antibacterial activity, noncompetitive inhibitor, binds at an allosteric site	Agaricus bisporus
sophoraflavanone G	from the root of Sophora flavescens, exhibits potent antibacterial activity, noncompetitive inhibitor	Agaricus bisporus

Organism

Organism	UniProt	Comment	Textmining
Agaricus bisporus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Agaricus bisporus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3,4-dihydroxyphenylalanine + 1/2 O2	-	Agaricus bisporus	dopaquinone + H2O	-	?
L-tyrosine + O2 + AH2	-	Agaricus bisporus	L-3,4-dihydroxyphenylalanine + H2O + A	-	?

Synonyms

Synonyms	Comment	Organism
monophenol, polyphenol oxidase	-	Agaricus bisporus
tyrosinase	-	Agaricus bisporus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	enzyme assay at	Agaricus bisporus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.5	-	enzyme assay at	Agaricus bisporus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000045	-	kurarinol	-	Agaricus bisporus
0.0041	-	kurarinone	-	Agaricus bisporus
0.0074	-	sophoraflavanone G	-	Agaricus bisporus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0001	-	-	Agaricus bisporus	kurarinol
0.0022	-	-	Agaricus bisporus	kurarinone
0.0047	-	-	Agaricus bisporus	sophoraflavanone G

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Release 2023.1 (January 2023)