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Literature summary for 1.14.18.1 extracted from

  • Momtaz, S.; Mapunya, B.M.; Houghton, P.J.; Edgerly, C.; Hussein, A.; Naidoo, S.; Lall, N.
    Tyrosinase inhibition by extracts and constituents of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening (2008), J. Ethnopharmacol., 119, 507-512.
    View publication on PubMed

Application

Application Comment Organism
drug development the bark extract of Sideroxylon inerme, epigallocatechin gallate and procyanidin B1 warrant further investigation in clinical studies to be considered as skin-depigmenting agents Agaricus bisporus

Inhibitors

Inhibitors Comment Organism Structure
arbutin
-
Agaricus bisporus
epigallocatechin gallate exhibits a greater anti-tyrosinase activity than arbutin Agaricus bisporus
kojic acid
-
Agaricus bisporus
additional information extracts and constituents of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening. Three different extracts (acetone, methanol and dichloromethane) of Sideroxylon inerme L. are evaluated for their inhibitory effect in vitro on the monophenolase and diphenolase activated forms of tyrosinase, using a colorimetric procedure Agaricus bisporus
procyanidin B1
-
Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Agaricus bisporus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-dopa + 1/2 O2
-
Agaricus bisporus L-dopaquinone + H2O
-
?
L-tyrosine + O2 + AH2
-
Agaricus bisporus L-dopa + H2O + A
-
?

Synonyms

Synonyms Comment Organism
tyrosinase
-
Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
methanolic and acetonic extracts of the stem bark of Sideroxylon inerme show significant inhibition of monophenolase activity (IC50 values of 63 microg/ml and 82 microg/ml). The methanolic extract also exhibits 37% reduction of melanin content at 6.2 microg/ml in melanocytes without being significantly toxic to the cells Agaricus bisporus additional information
0.008
-
-
Agaricus bisporus kojic acid
0.0655
-
-
Agaricus bisporus epigallocatechin gallate
0.346
-
-
Agaricus bisporus procyanidin B1
548
-
-
Agaricus bisporus arbutin