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Literature summary for 1.14.18.1 extracted from
- Identification of tyrosinase inhibitors from Marrubium velutinum and Marrubium cylleneum (2007), Bioorg. Med. Chem., 15, 2708-2714.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (7S, 8R, 8'R)-(-)-lariciresinol-4'-O-beta-D-glucopyranoside | tyrosinase inhibitors from Marrubium velutinum, lignan glucosides | Agaricus bisporus |  |
| (7S, 8R, 8'R)-(-)-lariciresinol-4,4'-O-bis-beta-D-glucopyranoside | tyrosinase inhibitors from Marrubium velutinum, lignan glucosides | Agaricus bisporus | |
| (7S, 8R, 8'R)-(-)-lariciresinol-4-O-beta-D-glucopyranoside | tyrosinase inhibitors from Marrubium velutinum, lignan glucosides | Agaricus bisporus | |
| 5,6,7,4'-tetramethylscutellarein | tyrosinase inhibitors from Marrubium velutinum, flavones/flavonols. Methoxylated flavones, like the methylethers of scutellarein, showed 10times lower inhibitory activity than kojic acid | Agaricus bisporus | |
| 5,6,7,8,4'-pentahydroxyflavone | tyrosinase inhibitors from Marrubium cylleneum, flavones/flavonols | Agaricus bisporus | |
| 5,7,4'-trimethylscutellarein | tyrosinase inhibitors from Marrubium velutinum, flavones/flavonols. Methoxylated flavones, like the methylethers of scutellarein, showed 10times lower inhibitory activity than kojic acid | Agaricus bisporus | |
| 6'-glucosyl-martynoside | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Bathochromic shift of 6'-glucosyl-martynoside in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
| 6-hydroxy-kaempferol-3-O-rutinoside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol glucosides | Agaricus bisporus | |
| acteoside | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Bathochromic shift of acteoside in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
| alyssonoside | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides | Agaricus bisporus | |
| apigenin | tyrosinase inhibitors from Marrubium velutinum, flavones/flavonols | Agaricus bisporus | |
| apigenin-7-O-(3'',6''-di-p-coumaroyl)-glucoside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| apigenin-7-O-(6''-p-coumaroyl)-glucoside | tyrosinase inhibitors from Marrubium cylleneum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| chlorogenic acid | tyrosinase inhibitors from Marrubium velutinum, phenolic acids | Agaricus bisporus | |
| chrysoeriol | tyrosinase inhibitors from Marrubium velutinum, flavones/flavonols | Agaricus bisporus | |
| chrysoeriol-7-O-(3'',6''-di-p-coumaroyl)-glucoside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| cistanoside F | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Comparing the activity of tetrasaccharides with cistanoside F | Agaricus bisporus | |
| echinacoside | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Bathochromic shift of echinacoside in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
| ferulic acid | tyrosinase inhibitors from Marrubium cylleneum, phenolic acids | Agaricus bisporus | |
| forsythoside B | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Bathochromic shift of for sythoside B in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
| isoferulate | tyrosinase inhibitors from Marrubium cylleneum, phenolic acids | Agaricus bisporus | |
| isorhamnetin-3-O-(6''-OAc)-glucoside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| isorhamnetin-3-O-glucoside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol glucosides | Agaricus bisporus | |
| isorhamnetin-3-O-rutinoside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol glucosides | Agaricus bisporus | |
| isorhamnetin-7-O-(6''-p-coumaroyl)-glucoside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| kaempferol-3-O-(6''-p-coumaroyl)-glucoside | tyrosinase inhibitors from Marrubium velutinum and Marrubium cylleneum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| kaempferol-3-O-glucoside | tyrosinase inhibitors from Marrubium cylleneum, flavone/flavonol glucosides | Agaricus bisporus | |
| kojic acid | postive control | Agaricus bisporus | |
| ladanein | tyrosinase inhibitors from Marrubium velutinum, flavones/flavonols. Methoxylated flavones, like the methylethers of scutellarein, showed 10times lower inhibitory activity than kojic acid | Agaricus bisporus | |
| lamiophlomiside | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides | Agaricus bisporus | |
| lavandulifolioside | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Bathochromic shift of lavandulifolioside in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
| leucosceptoside A | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Bathochromic shift of leucosceptoside A in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
| luteolin-7-O-glucoside | tyrosinase inhibitors from Marrubium cylleneum, flavone/flavonol glucosides | Agaricus bisporus | |
| martynoside | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides | Agaricus bisporus | |
| additional information | flavonoids and phenylethanoid glycosides show moderate inhibitory activity against tyrosinase (almost 2-3times weaker than kojic acid). In general at lower concentrations activity descends as flavonols > flavones > acylated monoglycosides > monoglycosides > diglycosides | Agaricus bisporus | |
| nikotiflorin | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol glucosides | Agaricus bisporus | |
| p-coumaric acid | tyrosinase inhibitors from Marrubium cylleneum, phenolic acids | Agaricus bisporus | |
| phaselic acid | tyrosinase inhibitors from Marrubium velutinum, phenolic acids | Agaricus bisporus | |
| quercetin | tyrosinase inhibitors from Marrubium cylleneum, flavones/flavonols | Agaricus bisporus | |
| quercetin-3-O-(6''-p-coumaroyl)-glucoside | tyrosinase inhibitors from Marrubium cylleneum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| rutin | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol glucosides | Agaricus bisporus | |
| stachydrine | tyrosinase inhibitors from Marrubium cylleneum, lignan glucosides | Agaricus bisporus | |
| stachysoside D | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides | Agaricus bisporus | |
| tiliroside | tyrosinase inhibitors from Marrubium velutinum, flavone/flavonol acylated glucosides | Agaricus bisporus | |
| velutinoside I | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides | Agaricus bisporus | |
| velutinoside II | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides. Bathochromic shift of velutinoside II in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
| velutinoside III | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides | Agaricus bisporus | |
| velutinoside IV | tyrosinase inhibitors from Marrubium velutinum, phenylethanoid glycosides | Agaricus bisporus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| copper | copper containing enzyme. Bathochromic shift of selected phenylethanoid glycosides (0.01 mM) in the presence of CuSO4 (0.05 mM) | Agaricus bisporus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agaricus bisporus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Agaricus bisporus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-dopa + 1/2 O2 | - |
Agaricus bisporus | L-dopaquinone + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| polyphenol oxidase | - |
Agaricus bisporus |
| PPO | - |
Agaricus bisporus |
| tyrosinase | - |
Agaricus bisporus |
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