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Literature summary for 1.14.18.1 extracted from
- Inhibitory effects of kurarinol, kuraridinol, and trifolirhizin from Sophora flavescens on tyrosinase and melanin synthesis (2008), Biol. Pharm. Bull., 31, 154-158.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | kurarinol, kuraridinol, and trifolirhizin are candidates as skin-whitening agents | Agaricus bisporus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| kojic acid | inhibitory effects with kojic acid | Agaricus bisporus |  |
| kuraridinol | prenylated flavonoid from Sophora flavescens, isolated from the EtOAc fraction, inhibitory effects on tyrosinase and melanin synthesis. Inhibitory activity 20times more potent than that of the positive control, kojic acid. Kuraridinol is a chalcone compound belonging to the prenylated flavonoids | Agaricus bisporus | |
| kurarinol | prenylated flavonoid from Sophora flavescens, isolated from the EtOAc fraction, inhibitory effects on tyrosinase and melanin synthesis. Kurarinol is a prenylated flavanone and an effective inhibitor of alpha-glucosidase, beta-amylase, and cGMP phosphodiesterase-5, and also inhibits diacylglycerol acyltransferase activity | Agaricus bisporus | |
| additional information | compounds from Sophora flavescens are further tested for their inhibitory effects on melanogenesis in B16 melanoma cells. MeOH extract fraction, CH2Cl2 fraction, EtOAc fraction and, n-BuOH fraction from Sophora flavescens inhibit L-tyrosine oxidation catalyzed by tyrosinase in concentration dependent manner. EtOAc fraction has more potent inhibitory activity than the other fractions | Agaricus bisporus | |
| trifolirhizin | prenylated flavonoid from Sophora flavescens, isolated from the EtOAc fraction, inhibitory effects on tyrosinase and melanin synthesis | Agaricus bisporus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.4 | - |
L-tyrosine | in the presence of kuraridinol | Agaricus bisporus | |
| 2.9 | - |
L-tyrosine | in the presence of kurarinol | Agaricus bisporus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agaricus bisporus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Agaricus bisporus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
for tyrosinase inhibitory activity assay mushroom tyrosinase (1000 U/ml) used | Agaricus bisporus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + O2 + AH2 | - |
Agaricus bisporus | L-dopa + H2O + A | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| polyphenol oxidase | - |
Agaricus bisporus |
| PPO | - |
Agaricus bisporus |
| tyrosinase | - |
Agaricus bisporus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Agaricus bisporus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00039 | - |
kuraridinol | noncompetitive inhibition | Agaricus bisporus | |
| 0.014 | - |
kurarinol | noncompetitive inhibition | Agaricus bisporus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.88 | - |
potent tyrosinase inhibitory activity | Agaricus bisporus | kuraridinol | |
| 8.6 | - |
potent tyrosinase inhibitory activity | Agaricus bisporus | kurarinol | |
| 506.8 | - |
moderate inhibitory activity | Agaricus bisporus | trifolirhizin | |
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