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Literature summary for 1.14.18.1 extracted from
- Inhibitory compound of tyrosinase activity from the sprout of Polygonum hydropiper L. (Benitade) (2007), Biol. Pharm. Bull., 30, 595-597.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | (2R,3R)-taxifolin isolated from Benitade may possibly be a of new tyrosinase inhibitor alternative to cosmetic agents such as arbutin and kojic | Agaricus bisporus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2R,3R)-taxifolin | isolated from the sprout of Polygonum hydropiper L. (Benitade), inhibited 70% of tyrosinase activity at a concentration of 0.50 mM | Agaricus bisporus |  |
| 3,7,3',4'-taxifolin tetraacetate | assayed together with (2R,3R)-taxifolin | Agaricus bisporus | |
| 5,7,3',4'-taxifolin teramethyl ether | assayed together with (2R,3R)-taxifolin | Agaricus bisporus | |
| arbutin | - |
Agaricus bisporus | |
| kojic acid | - |
Agaricus bisporus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agaricus bisporus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + O2 + AH2 | - |
Agaricus bisporus | L-dopa + H2O + A | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phenol oxidase | - |
Agaricus bisporus |
| tyrosinase | - |
Agaricus bisporus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.24 | - |
- |
Agaricus bisporus | (2R,3R)-taxifolin | |
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