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Literature summary for 1.14.18.1 extracted from

  • Ha, S.K.; Koketsu, M.; Lee, K.; Choi, S.Y.; Park, J.H.; Ishihara, H.; Kim, S.Y.
    Inhibition of tyrosinase activity by N,N-unsubstituted selenourea derivatives (2005), Biol. Pharm. Bull., 28, 838—840.
    View publication on PubMed
Search for more literature for 1.14.18.1

Inhibitors

Inhibitors Comment Organism Structure
kojic acid IC50: 0.277 mM Agaricus bisporus
additional information melan-a cell viability after application of N,N-unsubstituted selenourea derivatives and kojic acid, overview Agaricus bisporus
N,N-unsubstituted selenourea derivatives 55.5% inhibition at 0.2 mM, IC50: 0.17-0.23 mM Agaricus bisporus
Phenylthiourea IC50: 0.17 mM Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Agaricus bisporus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 determination of melanin levels Agaricus bisporus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-dihydroxyphenylalanine + O2
-
 Agaricus bisporus ?
-
 ?

Synonyms

Synonyms Comment Organism
tyrosinase
-
 Agaricus bisporus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.17
-
 IC50: 0.17 mM Agaricus bisporus Phenylthiourea
0.17 0.23 55.5% inhibition at 0.2 mM, IC50: 0.17-0.23 mM Agaricus bisporus N,N-unsubstituted selenourea derivatives
0.277
-
 IC50: 0.277 mM Agaricus bisporus kojic acid