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Literature summary for 1.14.17.3 extracted from
- Reversal of physiological deficits caused by diminished levels of peptidylglycine alpha-amidating monooxygenase by dietary copper (2009), Endocrinology, 150, 1739-1747.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| copper | - |
Mus musculus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 87000 | - |
determined by SDS-PAGE and Western Blot analysis | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | PAM is the only enzyme capable of amidating peptides, amidated peptides are numerous | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hypothalamus | - |
Mus musculus | - |
| pituitary gland | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.000012 | - |
PAM+/- mouse, POA, hypothalamus | Mus musculus |
| 0.000015 | - |
PAM+/- mouse, PVN, hypothalamus | Mus musculus |
| 0.000037 | - |
wild-type mouse, POA, hypothalamus | Mus musculus |
| 0.00004 | - |
wild-type mouse, PVN, hypothalamus | Mus musculus |
| 0.000043 | - |
PAM+/- mouse, pituitary | Mus musculus |
| 0.00008 | - |
wild-type mouse, pituitary | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | PAM is the only enzyme capable of amidating peptides, amidated peptides are numerous | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PAM | - |
Mus musculus |
| peptidylglycine alpha-amidating monooxygenase | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | regulation of the hypothalamic-pituitary-thyroid axis and body temperature are selected for evaluation | Mus musculus |
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Release 2023.1 (January 2023)
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