Literature summary for 1.14.17.3 extracted from

Sunman, J.A.; Foster, M.S.; Folse, S.L.; May, S.W.; Matesic, D.F.
Reversal of the transformed phenotype and inhibition of peptidylglycine alpha-monooxygenase in Ras-transformed cells by 4-phenyl-3-butenoic acid (2004), Mol. Carcinog., 41, 231-246.

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Application

Application	Comment	Organism
medicine	enzyme is an attractive target for anti-tumor compounds	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
4-Phenyl-3-butenoic acid	irreversible turnover-dependent inhibition of the enzyme in vitro, at 0.1 mg/ml inhibition in vivo of proliferation of lung cancer cells and Ras-transformed WB rat liver epithelial cells, inhibitor leads to increased gap junction communication in the WB-Ras cells, overview	Homo sapiens
4-phenyl-3-butenoic acid methyl ester	at 0.01 mg/ml inhibition in vivo of proliferation of Ras-transformed WB rat liver epithelial cells, inhibitor leads to increased gap junction communication in the WB-Ras cells, overview	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Homo sapiens	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	enzyme is required for amidation of autocrine growth factors causing proliferation in tumor cells	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	bifunctional enzyme	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme is required for amidation of autocrine growth factors causing proliferation in tumor cells	Homo sapiens	?	-	?
N-trinitrophenyl-D-Tyr-Val-Gly + ascorbate + O2	-	Homo sapiens	N-trinitrophenyl-D-Tyr-Val-(2-hydroxyglycine) + dehydroascorbate + H2O	the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide	?

Synonyms

Synonyms	Comment	Organism
PAM	-	Homo sapiens
peptidylglycine alpha-monooxygenase	-	Homo sapiens

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Release 2023.1 (January 2023)