Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, phylogenetic analysis | Dugesia japonica |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | localization around the nuclei | Dugesia japonica | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
copper | essentially required for activity, 2 atoms bound by 5 conserved His residues and 1 conserved Met residue | Dugesia japonica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Dugesia japonica | enzyme is required for amidation of the C-terminus of neuropeptides | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dugesia japonica | Q4W7B5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | neuronal cell bodies, axon bundles | Dugesia japonica | - |
eye | expression only in the photoreceptor cells adjacent to the eye cup | Dugesia japonica | - |
additional information | tissue expression pattern, the enzyme colocalizes with cytochrome b561 along the central nervous system | Dugesia japonica | - |
neuron | - |
Dugesia japonica | - |
ventral nerve cord | - |
Dugesia japonica | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme is required for amidation of the C-terminus of neuropeptides | Dugesia japonica | ? | - |
? | |
peptidylglycine + ascorbate + O2 | peptidylglycine alpha-hydroxylating monooxygenase PHM reaction | Dugesia japonica | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide | ? |
Synonyms | Comment | Organism |
---|---|---|
peptidylglycine alpha-hydroxylating monooxygenase | - |
Dugesia japonica |
PHM | - |
Dugesia japonica |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ascorbate | - |
Dugesia japonica |