Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-Phenyl-3-butenoic acid | mechanism-based inhibition | Bos taurus | |
Monoethyl fumarate | mechanism-based inhibition | Bos taurus | |
trans-Benzoylacrylic acid | mechanism-based inhibition | Bos taurus | |
[(4-Methoxybenzoyl)oxy]acetic acid | - |
Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidylglycine + ascorbate + O2 | Bos taurus | - |
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
[peptide]-glycine + 2 ascorbate + O2 = [peptide]-(2S)-2-hydroxyglycine + 2 monodehydroascorbate + H2O | mechanism | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PAM catalyzes: 1. sulfoxidation of e.g. (4-nitrobenzyl) thioacetic acid to the analogous sulfoxide, 2. amine N-dealkylation of e.g. N-(4-nitrobenzyl)glycine to 4-nitrobenzylamine and glyoxylate, 3. O-dealkylation of e.g. [(4-nitrobenzyl)oxy]acetic acid to 4-nitrobenzyl alcohol and glyoxylate, 4. transformation of hippuric acid and several ring-substituted derivatives to the corresponding benzoamides and glyoxylic acid | Bos taurus | ? | - |
? | |
N-(4-nitrobenzyl)glycine + ascorbate + O2 | - |
Bos taurus | nitrobenzylamine + glyoxylate + dehydroascorbate + H2O | - |
? | |
peptidylglycine + ascorbate + O2 | - |
Bos taurus | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? | |
peptidylglycine + ascorbate + O2 | COOH-terminal glycine | Bos taurus | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? | |
[(4-nitrobenzyl)oxy]acetic acid + ascorbate + O2 | - |
Bos taurus | nitrobenzyl alcohol + glyoxylate + dehydroascorbate + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ascorbate | dependent on | Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
4-Phenyl-3-butenoic acid | strictly ascorbate dependent | Bos taurus | |
0.16 | - |
trans-Benzoylacrylic acid | - |
Bos taurus | |
0.48 | - |
[(4-Methoxybenzoyl)oxy]acetic acid | - |
Bos taurus | |
1.3 | - |
Monoethyl fumarate | - |
Bos taurus |