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Literature summary for 1.14.17.3 extracted from

  • Katapodis, A.G.; May, S.W.
    Novel substrates and inhibitors of peptidylglycine alpha-amidating monooxygenase (1990), Biochemistry, 29, 4541-4548.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-Phenyl-3-butenoic acid mechanism-based inhibition Bos taurus
Monoethyl fumarate mechanism-based inhibition Bos taurus
trans-Benzoylacrylic acid mechanism-based inhibition Bos taurus
[(4-Methoxybenzoyl)oxy]acetic acid
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidylglycine + ascorbate + O2 Bos taurus
-
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
[peptide]-glycine + 2 ascorbate + O2 = [peptide]-(2S)-2-hydroxyglycine + 2 monodehydroascorbate + H2O mechanism Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PAM catalyzes: 1. sulfoxidation of e.g. (4-nitrobenzyl) thioacetic acid to the analogous sulfoxide, 2. amine N-dealkylation of e.g. N-(4-nitrobenzyl)glycine to 4-nitrobenzylamine and glyoxylate, 3. O-dealkylation of e.g. [(4-nitrobenzyl)oxy]acetic acid to 4-nitrobenzyl alcohol and glyoxylate, 4. transformation of hippuric acid and several ring-substituted derivatives to the corresponding benzoamides and glyoxylic acid Bos taurus ?
-
?
N-(4-nitrobenzyl)glycine + ascorbate + O2
-
Bos taurus nitrobenzylamine + glyoxylate + dehydroascorbate + H2O
-
?
peptidylglycine + ascorbate + O2
-
Bos taurus peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
?
peptidylglycine + ascorbate + O2 COOH-terminal glycine Bos taurus peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
?
[(4-nitrobenzyl)oxy]acetic acid + ascorbate + O2
-
Bos taurus nitrobenzyl alcohol + glyoxylate + dehydroascorbate + H2O
-
?

Cofactor

Cofactor Comment Organism Structure
ascorbate dependent on Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.001
-
4-Phenyl-3-butenoic acid strictly ascorbate dependent Bos taurus
0.16
-
trans-Benzoylacrylic acid
-
Bos taurus
0.48
-
[(4-Methoxybenzoyl)oxy]acetic acid
-
Bos taurus
1.3
-
Monoethyl fumarate
-
Bos taurus