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Literature summary for 1.14.17.1 extracted from

  • Rahman, M.K.; Choudhary, M.I.; Islam, M.R.; Hafizur, R.M.
    Developmental changes of catecholamine-mediating enzyme - dopamine-beta-hydroxylase and its cofactors in central and peripheral tissues and serum of long-evans rats (2012), Int. J. Biomed. Sci., 8, 194-203.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.5 2 tyramine enzyme from serum of 5-weeks-old rats, at 37°C, pH not specified in the publication Rattus norvegicus
0.79
-
tyramine enzyme from serum of 2-weeks-old rats, at 37°C, pH not specified in the publication Rattus norvegicus
0.92
-
tyramine enzyme from serum of 8-weeks-old rats, at 37°C, pH not specified in the publication Rattus norvegicus
1.22
-
tyramine enzyme from serum of 1-weeks-old rats, at 37°C, pH not specified in the publication Rattus norvegicus
1.37
-
tyramine enzyme from serum of 12-weeks-old rats, at 37°C, pH not specified in the publication Rattus norvegicus
1.6
-
tyramine enzyme from serum of 15-weeks-old rats, at 37°C, pH not specified in the publication Rattus norvegicus
2.1
-
tyramine enzyme from serum of 27-weeks-old rats, at 37°C, pH not specified in the publication Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dopamine + ascorbate + O2 Rattus norvegicus
-
norepinephrine + dehydroascorbate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Rattus norvegicus
-
brain highest activity Rattus norvegicus
-
brain stem
-
Rattus norvegicus
-
caudate nucleus
-
Rattus norvegicus
-
cerebellum
-
Rattus norvegicus
-
cerebral cortex
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
hypothalamus
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
lung
-
Rattus norvegicus
-
midbrain colliculus
-
Rattus norvegicus
-
pancreas
-
Rattus norvegicus
-
serum
-
Rattus norvegicus
-
small intestine
-
Rattus norvegicus
-
spleen
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dopamine + ascorbate + O2
-
Rattus norvegicus norepinephrine + dehydroascorbate + H2O
-
?
tyramine + ascorbate + O2
-
Rattus norvegicus octopamine + dehydroascorbate + H2O
-
?

Synonyms

Synonyms Comment Organism
3,4-dihydroxy-phenylethylamine, ascorbate: oxygen oxidoreductase (3-hydroxylating)
-
Rattus norvegicus
DBH
-
Rattus norvegicus
dopamine-beta-hydroxylase
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus enzyme expression is highest in 5-weeks-old rats up