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Literature summary for 1.14.17.1 extracted from
- Copper deficiency in rodents alters dopamine beta-mono-oxygenase activity, mRNA and protein level (2009), Br. J. Nutr., 102, 18-28.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | adequate dietary Cu is essential to support DBM function in vivo | Mus musculus |
| medicine | adequate dietary Cu is essential to support DBM function in vivo | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | Cu deficiency limits DBM activity in vivo | Rattus norvegicus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 75000 | - |
Western blot analysis | Mus musculus |
| 75000 | - |
Western blot analysis | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
Hsd:ICR (CD-1) outbred albino mice, postnatal day 27 male mice and day 28 male mice | - |
| Rattus norvegicus | - |
Holtzman rats, postnatal day 24 male rats and day 26 male rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Mus musculus | - |
| adrenal gland | - |
Rattus norvegicus | - |
| heart | lowest level of all tissues | Rattus norvegicus | - |
| additional information | medulla oblongata/pons | Rattus norvegicus | - |
| vas deferens | - |
Rattus norvegicus | - |
| vas deferens | DBM protein is present in Cu-negative samples but not in Cu-positive samples | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| tyramine + ascorbate + O2 | - |
Mus musculus | octopamine + dehydroascorbate + H2O | - |
? |  |
| tyramine + ascorbate + O2 | - |
Rattus norvegicus | octopamine + dehydroascorbate + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DBM | - |
Mus musculus |
| DBM | - |
Rattus norvegicus |
| dopamine beta-mono-oxygenase | - |
Mus musculus |
| dopamine beta-mono-oxygenase | - |
Rattus norvegicus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | Cu-negative samples have significantly higher DBM activity than Cu-positive samples in both adrenal glands (2.4fold) and medulla oblongata/pons (0.9fold), but not vas deferens. No correlation between higher DBM mRNA and lower noradrenaline in Cu-negative tissues | up |
| Mus musculus | DBM protein abundance in adrenal glands is higher in the Cu-negative samples compared with Cu-positive samples | up |
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Release 2023.1 (January 2023)
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