Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.17.1 extracted from

  • Narita, M.; Ishida, T.; Tomoyoshi, T.; Nozaki, M.; Horiike, K.
    A natural variant of bovine dopamine beta-monooxygenase with phenylalanine as residue 208: purification and characterization of the variant homo- and heterotetramers of (F208)4 and (F208)2(L208)2 (1996), FEBS Lett., 396, 208-212.
    View publication on PubMed
Search for more literature for 1.14.17.1

Protein Variants

Protein Variants Comment Organism
L208F a natural variant - three phenotypes of enzyme isolated: 4 * L208-homoenzyme, 4 * F208-homoenzyme and 2 * F208, 2 * L208-heteroenzyme, no significant difference in kinetic properties Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
65000
-
 4 * 65000, deduced from cDNA Bos taurus
220000 250000 220000 Da, L208 homoenzyme, 230000 Da, F208 homoenzyme, 250000 Da, F208/L208 heteroenzyme, low-angle laser light scattering-photometry Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,4-dihydroxyphenethylamine + ascorbate + O2 Bos taurus enzyme plays a key role in the biosynthetic interconversion of neurotransmitters noradrenaline + dehydroascorbate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-dihydroxyphenethylamine + ascorbate + O2
-
 Bos taurus noradrenaline + dehydroascorbate + H2O
-
 ?
3,4-dihydroxyphenethylamine + ascorbate + O2 enzyme plays a key role in the biosynthetic interconversion of neurotransmitters Bos taurus noradrenaline + dehydroascorbate + H2O
-
 ?
tyramine + ascorbate + O2
-
 Bos taurus octopamine + dehydroascorbate + H2O
-
 ?

Subunits

Subunits Comment Organism
tetramer 4 * 65000, deduced from cDNA Bos taurus