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Literature summary for 1.14.17.1 extracted from

  • Colombo, G.; Rajashekhar, B.; Giedroc, D.P.; Villafranca, J.J.
    Mechanism-based inhibitors of dopamine beta-hydroxylase: inhibition by 2-bromo-3-(p-hydroxyphenyl)-1-propene (1984), Biochemistry, 23, 3590-3598.
    View publication on PubMed
Search for more literature for 1.14.17.1

Inhibitors

Inhibitors Comment Organism Structure
2-Bromo-3-(p-hydroxyphenyl)-1-propene mechanism-based inhibition Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.9
-
 2-Bromo-3-(p-hydroxyphenyl)-1-propene
-
 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
chromaffin granule
-
 Bos taurus 42583
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-bromo-3-(p-hydroxyphenyl)-1-propene + ascorbate + O2
-
 Bos taurus 2-bromo-3-hydroxy-3-(p-hydroxyphenyl)-1-propene + H2O
-
 ?
3,4-dihydroxyphenethylamine + ascorbate + O2
-
 Bos taurus noradrenaline + dehydroascorbate + H2O norepinephrine ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.223
-
 2-Bromo-3-(p-hydroxyphenyl)-1-propene
-
 Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.9
-
 2-Bromo-3-(p-hydroxyphenyl)-1-propene
-
 Bos taurus