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Literature summary for 1.14.17.1 extracted from

  • May, S.W.; Mueller, P.W.; Padgette, S.R.; Herman, H.H.; Phillips, R.S.
    Dopamine-beta-hydroxylase: suicide inhibition by the novel olefinic substrate, 1-phenyl-1-aminomethylethene (1983), Biochem. Biophys. Res. Commun., 110, 161-168.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-Phenyl-1-aminomethylethene suicide inhibition Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7
-
Phenylethylamine
-
Bos taurus
8.3
-
1-Phenyl-1-aminomethylethene
-
Bos taurus
14
-
octopamine
-
Bos taurus
20.4
-
3-Phenylpropylamine
-
Bos taurus
26.5
-
phenyl 2-aminoethyl sulfide
-
Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,4-dihydroxyphenethylamine + ascorbate + O2 Bos taurus enzyme plays a key role in the biosynthetic interconversion of neurotransmitters noradrenaline + dehydroascorbate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phenyl-1-aminomethylethene + ascorbate + O2 ascorbate and ferrocyanide can function as a electron donors Bos taurus 2,3-dihydroxy-2-phenylpropylamine + dehydroascorbate + H2O + ?
-
?
1-phenylethylamine + ascorbate + O2
-
Bos taurus ?
-
?
2-phenylethylamine + ascorbate + O2
-
Bos taurus ?
-
?
3,4-dihydroxyphenethylamine + ascorbate + O2
-
Bos taurus noradrenaline + dehydroascorbate + H2O norepinephrine ?
3,4-dihydroxyphenethylamine + ascorbate + O2 enzyme plays a key role in the biosynthetic interconversion of neurotransmitters Bos taurus noradrenaline + dehydroascorbate + H2O
-
?
3-phenylpropylamine + ascorbate + O2
-
Bos taurus ?
-
?
N-phenylethylenediamine + ascorbate + O2
-
Bos taurus ?
-
?
octopamine + ascorbate + O2
-
Bos taurus ?
-
?
phenyl 2-aminoethyl sulfide + ascorbate + O2
-
Bos taurus phenyl-2-aminoethyl sulfoxide + dehydroascorbate + H2O
-
?
phenylaminoethyl sulfide + ascorbate + O2
-
Bos taurus ?
-
?

Synonyms

Synonyms Comment Organism
dopamine-B-hydroxylase DBH Bos taurus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
10
-
1-Phenyl-1-aminomethylethene
-
Bos taurus
12
-
3-Phenylpropylamine
-
Bos taurus
33
-
octopamine
-
Bos taurus
65
-
1-Phenylethylamine
-
Bos taurus
68
-
Phenylaminoethyl sulfide
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
13
-
1-Phenyl-1-aminomethylethene
-
Bos taurus