Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.16.5 extracted from

  • Tokuoka, S.M.; Kita, Y.; Shindou, H.; Shimizu, T.
    Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages (2013), Biochem. Biophys. Res. Commun., 436, 306-312.
    View publication on PubMed
Search for more literature for 1.14.16.5

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
D233A inactive Mus musculus
Q197A the mutant retains minimal activity Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
 x * 48000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine + tetrahydrobiopterin + O2 Mus musculus 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine is lyso-platelet activating factor glycerophosphocholine + alkylaldehyde + dihydrobiopterin + H2O
-
 ?
1-O-alkyl-sn-glycerol + tetrahydrobiopterin + O2 Mus musculus
-
 1-O-(1-hydroxyalkyl)-sn-glycerol + dihydrobiopterin + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
peritoneal macrophage
-
 Mus musculus
-
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine + tetrahydrobiopterin + O2 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine is lyso-platelet activating factor Mus musculus glycerophosphocholine + alkylaldehyde + dihydrobiopterin + H2O
-
 ?
1-O-alkyl-sn-glycerol + tetrahydrobiopterin + O2
-
 Mus musculus 1-O-(1-hydroxyalkyl)-sn-glycerol + dihydrobiopterin + H2O
-
 ?

Subunits

Subunits Comment Organism
? x * 48000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
AGMO
-
 Mus musculus
glyceryl ether monooxygenase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
tetrahydrobiopterin dependent on Mus musculus

Expression

Organism Comment Expression
Mus musculus mRNA expression levels decrease with lipopolysaccharide treatments in mouse peritoneal macrophages and RAW264.7 cells down

General Information

General Information Comment Organism
physiological function the enzyme modulates macrophage macrophage platelet-activating factor production by regulating cellular lyso-platelet-activating factor levels Mus musculus