Literature summary for 1.14.16.4 extracted from

Tzvetkov, M.V.; Brockmoeller, J.; Roots, I.; Kirchheiner, J.
Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment (2008), Pharmacogenet. Genomics, 18, 495-506.

Search for more literature for 1.14.16.4

Cloned(Commentary)

Cloned (Comment)	Organism
gene TPH2 located on the long arm of chromosome 12 at 12q21.1, DNA and amino acid sequence determination and analysis, genotyping	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	naturally occuring single nucleotide polymorphisms rs4570625, rs1386494, rs10897346 and rs1487278 are associated with major depression and the patients carrying these mutations respond to therapy, determination of clinical and molecular predictors, overview	Homo sapiens
R441H	a naturally occuring single nucleotide polymorphism	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	Homo sapiens	-	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8IWU9	depressive patients, gene TPH2	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	-	Homo sapiens	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Synonyms

Synonyms	Comment	Organism
TPH2	-	Homo sapiens
tryptophan hydroxylase-2	-	Homo sapiens

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Release 2023.1 (January 2023)