Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | fluoxetine treatment for 4 and 8 weeks significantly increases basal TPH2 mRNA levels in the midbrain, correlated with the appearance of antidepressant-like effects in the forced swim test, co-induction of TPH2 and the 5-hydroxytryptamine transporter expression, overview | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Rattus norvegicus | TPH2 is the rate-limiting enzyme in 5-hydroxytryptamine, i.e. serotonin, biosynthesis in the brain, and is a candidate for participation in a mechanism mediating the antidepressant effect of selective 5-hydroxytryptamine reuptake inhibitors such as fluoxetine, TPH2 gene expression in the midbrain part of the dorsal raphenucleus is implicated in depression and stress response | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q8CGU9 | male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | expression analysis of TPH2 | Rattus norvegicus | - |
brain stem | TPH2 mRNA expression in the midbrain part of the dorsal raphe nucleus and in the brainstem containing the rest of the raphe complex | Rattus norvegicus | - |
midbrain | TPH2 mRNA expression in the midbrain part of the dorsal raphe nucleus and in the brainstem containing the rest of the raphe complex | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | TPH2 is the rate-limiting enzyme in 5-hydroxytryptamine, i.e. serotonin, biosynthesis in the brain, and is a candidate for participation in a mechanism mediating the antidepressant effect of selective 5-hydroxytryptamine reuptake inhibitors such as fluoxetine, TPH2 gene expression in the midbrain part of the dorsal raphenucleus is implicated in depression and stress response | Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH2 | - |
Rattus norvegicus |
tryptophan hydroxylase-2 | - |
Rattus norvegicus |