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Literature summary for 1.14.16.4 extracted from

  • Shishkina, G.T.; Kalinina, T.S.; Dygalo, N.N.
    Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect (2007), Neuroscience, 150, 404-412.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information fluoxetine treatment for 4 and 8 weeks significantly increases basal TPH2 mRNA levels in the midbrain, correlated with the appearance of antidepressant-like effects in the forced swim test, co-induction of TPH2 and the 5-hydroxytryptamine transporter expression, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Rattus norvegicus TPH2 is the rate-limiting enzyme in 5-hydroxytryptamine, i.e. serotonin, biosynthesis in the brain, and is a candidate for participation in a mechanism mediating the antidepressant effect of selective 5-hydroxytryptamine reuptake inhibitors such as fluoxetine, TPH2 gene expression in the midbrain part of the dorsal raphenucleus is implicated in depression and stress response 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q8CGU9 male Wistar rats
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Source Tissue

Source Tissue Comment Organism Textmining
brain expression analysis of TPH2 Rattus norvegicus
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brain stem TPH2 mRNA expression in the midbrain part of the dorsal raphe nucleus and in the brainstem containing the rest of the raphe complex Rattus norvegicus
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midbrain TPH2 mRNA expression in the midbrain part of the dorsal raphe nucleus and in the brainstem containing the rest of the raphe complex Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
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Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
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?
L-tryptophan + tetrahydrobiopterin + O2 TPH2 is the rate-limiting enzyme in 5-hydroxytryptamine, i.e. serotonin, biosynthesis in the brain, and is a candidate for participation in a mechanism mediating the antidepressant effect of selective 5-hydroxytryptamine reuptake inhibitors such as fluoxetine, TPH2 gene expression in the midbrain part of the dorsal raphenucleus is implicated in depression and stress response Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Synonyms

Synonyms Comment Organism
TPH2
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Rattus norvegicus
tryptophan hydroxylase-2
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Rattus norvegicus