Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.16.4 extracted from

  • Watanabe, Y.; Nunokawa, A.; Kaneko, N.; Someya, T.
    The tryptophan hydroxylase 1 (TPH1) gene and risk of schizophrenia: a moderate-scale case-control study and meta-analysis (2007), Neurosci. Res., 59, 322-326.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene TPH1, genotyping in Japanese population of healthy persons and shizophrenia patients Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information determination and analysis of single nucleotide polymorphisms in Japanese subjects, rs10741734, rs211102, rs10488683, rs9633898, rs1800532 and rs4537731, genotyping, analysis of correlations with schizophrenia in a case-control association study, and meta-analysis, no significant associations between the polymorphisms or haplotypes of TPH1 and schizophrenia in the Japanese subjects, but possible involvement of the TPH1 218A allele in susceptibility to schizophrenia, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens TPH is the rate-limiting enzyme in the biosynthesis of 5-hydroxytryptamine, i.e. serotonin, possible involvement of the TPH1 218A allele in susceptibility to schizophrenia, overview 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
Japanese individuals
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2 TPH is the rate-limiting enzyme in the biosynthesis of 5-hydroxytryptamine, i.e. serotonin, possible involvement of the TPH1 218A allele in susceptibility to schizophrenia, overview Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Synonyms

Synonyms Comment Organism
TPH1
-
Homo sapiens
tryptophan hydroxylase 1
-
Homo sapiens