Cloned (Comment) | Organism |
---|---|
DNA and amio acid sequence determination and analysis of short and long isozymes TPH2, expression analysis in brain | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a naturally occuring mutation in exon 6, g.22879A-G, a single nucleotide polymorphism, causes truncation of the enzyme to the native short form of brain-specific isozyme TPH2, which causes impaired serotonin transmission and depression, phenotype, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | brain-specific isozyme TPH2 is the rate-limiting enzyme in serotonin biosynthesis, a truncated enzyme version occurs in brain tissues being the cause of impaired serotonin transmission | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IWU9 | Caucasian individuals | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amygdala | expression of the native truncated mutant TPH2 | Homo sapiens | - |
brain | specific expression of isozyme TPH2 | Homo sapiens | - |
brain stem | expression of the native truncated mutant TPH2 | Homo sapiens | - |
hippocampus | expression of the native truncated mutant TPH2 | Homo sapiens | - |
neuron | neural isozyme TPH2 | Homo sapiens | - |
prefrontal cortex | expression of the native truncated mutant TPH2 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | brain-specific isozyme TPH2 is the rate-limiting enzyme in serotonin biosynthesis, a truncated enzyme version occurs in brain tissues being the cause of impaired serotonin transmission | Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH2 | - |
Homo sapiens |
tryptophan hydroxylase 2 | - |
Homo sapiens |
tryptophan hydroxylase-2 | - |
Homo sapiens |