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Literature summary for 1.14.16.4 extracted from
- Developmental role of tryptophan hydroxylase in the nervous system (2007), Mol. Neurobiol., 35, 45-54.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| isozyme TPH1, DNA and amino acid sequence determination and analysis, tissue-specific and developmental expression analysis, expression of His6-tagged TPH1 in COS7 cells | Mus musculus |
| isozyme TPH1, DNA and amino acid sequence determination and analysis, TPH1 is located on chromosome 11, expression analysis | Homo sapiens |
| isozyme TPH2, DNA and amino acid sequence determination and analysis, tissue-specific and developmental expression analysis, expression of His6-tagged TPH2 in COS7 cells | Mus musculus |
| isozyme TPH2, DNA and amino acid sequence determination and analysis, TPH2 is on chromosome 12, expression analysis | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A779C | naturally occuring polymorphism in intron 7 of TPH1 is associated with alcoholic offenders | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetic mechanism of isozyme TPH1 | Homo sapiens | |
| additional information | - |
additional information | kinetic mechanism of isozyme TPH1 | Mus musculus | |
| additional information | - |
additional information | kinetic mechanism of isozyme TPH2 | Mus musculus | |
| additional information | - |
additional information | kinetic mechanism of isozyme TPH2 | Homo sapiens | |
| 0.0075 | - |
L-tryptophan | TPH1, with 0.004 mM tetrahydrobiopterin | Mus musculus |  |
| 0.0166 | - |
L-tryptophan | TPH1, with 0.4 mM tetrahydrobiopterin | Mus musculus | |
| 0.0192 | - |
L-tryptophan | TPH2, with 0.004-0.4 mM tetrahydrobiopterin | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + tetrahydrobiopterin + O2 | Mus musculus | TPH catalyzes the first step and rate-limiting reaction in the biosynthesis of 5-hydroxytryptamine, i.e. serotonin, and plays a role in brain and serotonergic neuron development, also TPH1 is involved in behavioural disorders, overview | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
| L-tryptophan + tetrahydrobiopterin + O2 | Mus musculus | TPH catalyzes the first step and rate-limiting reaction in the biosynthesis of 5-hydroxytryptamine, i.e. serotonin, and plays a role in brain and serotonergic neuron development, overview | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
| L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | TPH catalyzes the first step and rate-limiting reaction in the biosynthesis of 5-hydroxytryptamine, i.e. serotonin, and plays a role in brain development, overview | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
| additional information | Homo sapiens | 5-hydroxytryptamine is a major modulator of behavior in vertebrates and invertebrates, and deficiencies in the serotonergic system account for several behavioral disorders in humans, 5-hydroxyytryptamine is a major therapeutic target in patients with psychiatric disorders, overview | ? | - |
? | |
| additional information | Homo sapiens | 5-hydroxytryptamine is a major modulator of behavior in vertebrates and invertebrates, and deficiencies in the serotonergic system account for several behavioral disorders in humans, 5-hydroxyytryptamine is a major therapeutic target in patients with psychiatric disorders, overview, association of TPH1 with suicidal behavior, TPH1 is involved in brain and serotonergic neuron development, overview | ? | - |
? | |
| additional information | Mus musculus | temporal expression pattern of TPH1 and pathway regulation, overview | ? | - |
? | |
| additional information | Mus musculus | temporal expression pattern of TPH2 and pathway regulation, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P17752 | isozyme TPH1; isozyme TPH1 | - |
| Homo sapiens | Q8IWU9 | isozyme TPH2; isozyme TPH2 | - |
| Mus musculus | P17532 | TPH1; isozyme TPH1 | - |
| Mus musculus | Q8CGV2 | TPH2; isozyme TPH2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | mainly TPH2 | Homo sapiens | - |
| brain | temporal expression pattern of TPH1 | Mus musculus | - |
| brain | temporal expression pattern of TPH2 | Mus musculus | - |
| brain | TPH1 is expressed predominantly during the late developmental stage in the brain | Homo sapiens | - |
| gut | TPH2 | Homo sapiens | - |
| mastocytoma cell | - |
Mus musculus | - |
| additional information | TPH1 mRNA is mainly expressed in the pineal gland and the periphery | Homo sapiens | - |
| additional information | TPH2 mRNA is preferentially expressed in the brain and in the peripheral myenteric neurons in the gut | Homo sapiens | - |
| neuron | - |
Mus musculus | - |
| neuron | - |
Homo sapiens | - |
| pineal gland | TPH1 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + tetrahydrobiopterin + O2 | - |
Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
| L-tryptophan + tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
| L-tryptophan + tetrahydrobiopterin + O2 | TPH catalyzes the first step and rate-limiting reaction in the biosynthesis of 5-hydroxytryptamine, i.e. serotonin, and plays a role in brain and serotonergic neuron development, also TPH1 is involved in behavioural disorders, overview | Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
| L-tryptophan + tetrahydrobiopterin + O2 | TPH catalyzes the first step and rate-limiting reaction in the biosynthesis of 5-hydroxytryptamine, i.e. serotonin, and plays a role in brain and serotonergic neuron development, overview | Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
| L-tryptophan + tetrahydrobiopterin + O2 | TPH catalyzes the first step and rate-limiting reaction in the biosynthesis of 5-hydroxytryptamine, i.e. serotonin, and plays a role in brain development, overview | Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
| additional information | 5-hydroxytryptamine is a major modulator of behavior in vertebrates and invertebrates, and deficiencies in the serotonergic system account for several behavioral disorders in humans, 5-hydroxyytryptamine is a major therapeutic target in patients with psychiatric disorders, overview | Homo sapiens | ? | - |
? | |
| additional information | 5-hydroxytryptamine is a major modulator of behavior in vertebrates and invertebrates, and deficiencies in the serotonergic system account for several behavioral disorders in humans, 5-hydroxyytryptamine is a major therapeutic target in patients with psychiatric disorders, overview, association of TPH1 with suicidal behavior, TPH1 is involved in brain and serotonergic neuron development, overview | Homo sapiens | ? | - |
? | |
| additional information | temporal expression pattern of TPH1 and pathway regulation, overview | Mus musculus | ? | - |
? | |
| additional information | temporal expression pattern of TPH2 and pathway regulation, overview | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TPH | - |
Mus musculus |
| TPH | - |
Homo sapiens |
| TPH1 | - |
Homo sapiens |
| TPH1 | - |
Mus musculus |
| TPH2 | - |
Mus musculus |
| TPH2 | - |
Homo sapiens |
| tryptophan hydroxylase | - |
Mus musculus |
| tryptophan hydroxylase | - |
Homo sapiens |
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