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Literature summary for 1.14.16.4 extracted from

  • Calcagno, E.; Canetta, A.; Guzzetti, S.; Cervo, L.; Invernizzi, R.W.
    Strain differences in basal and post-citalopram extracellular 5-HT in the mouse medial prefrontal cortex and dorsal hippocampus: relation with tryptophan hydroxylase-2 activity (2007), J. Neurochem., 103, 1111-1120.
    View publication on PubMed
Search for more literature for 1.14.16.4

Activating Compound

Activating Compound Comment Organism Structure
additional information citalopram raises basal extracellular serotonin levels in DBA/2J, DBA/2N and BALB/c mice carrying the 1473G allele, but not in C57BL/6J and C57BL/6N mice carrying the 1473C allele, overview Mus musculus

Protein Variants

Protein Variants Comment Organism
G1473C naturally occuring polymorphism, citalopram raises basal extracellular serotonin levels in DBA/2J, DBA/2N and BALB/c mice carrying the 1473G allele, but not in C57BL/6J and C57BL/6N mice carrying the 1473C allele, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Mus musculus rate-limiting step in serotonin, i.e. 5-hydroxytryptamine, biosynthesis 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 DBA/2J, DBA/2N and BALB/c mice carrying the 1473G allele, and C57BL/6J and C57BL/6N mice carrying the 1473C allele
-

Source Tissue

Source Tissue Comment Organism Textmining
brain prefrontal cortex and dorsal hippocampus Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 determination of extracellular 4-hydroxytryptamine Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
 Mus musculus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
L-tryptophan + tetrahydrobiopterin + O2 rate-limiting step in serotonin, i.e. 5-hydroxytryptamine, biosynthesis Mus musculus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Synonyms

Synonyms Comment Organism
TPH2
-
 Mus musculus
tryptophan hydroxylase-2
-
 Mus musculus