Literature summary for 1.14.16.4 extracted from

Rhim, Y.T.; Kim, H.; Yoon, S.J.; Kim, S.S.; Chang, H.K.; Lee, T.H.; Lee, H.H.; Shin, M.C.; Shin, M.S.; Kim, C.J.
Effect of Acanthopanax senticosus on 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats (2007), J. Ethnopharmacol., 114, 38-43.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	Acanthopanax senticosus, as aqueous extracts from fresh stem braks, increases the time to exhaustion by treadmill running and it suppressed the exercise-induced increase of 5-hydroxytryptamine synthesis and TPH expression. Acanthopanax senticosus is effective as caffeine for increasing the exhaustion time in treadmill running and for reducing the exercise-induced increase of 5-hydroxytryptamine synthesis and TPH expression in the dorsal raphe, overview	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	Rattus norvegicus	TPH is involved in the biosynthesis of 5-hydroxytryptamine, i.e. serotonin, important neurotransmitters in the brain and involved in regulation of body temperature, blood pressure, endocrine activity, appetite, sexual behavior, movement, emesis, and pain, the enzyme activity plays a role in exercise-induced fatigue, overvieww	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male sprague-dawley rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	dorsal raphe nuclei	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	-	Rattus norvegicus	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + tetrahydrobiopterin + O2	TPH is involved in the biosynthesis of 5-hydroxytryptamine, i.e. serotonin, important neurotransmitters in the brain and involved in regulation of body temperature, blood pressure, endocrine activity, appetite, sexual behavior, movement, emesis, and pain, the enzyme activity plays a role in exercise-induced fatigue, overvieww	Rattus norvegicus	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Synonyms

Synonyms	Comment	Organism
TPH	-	Rattus norvegicus
tryptophan hydroxylase	-	Rattus norvegicus

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Release 2023.1 (January 2023)