Cloned (Comment) | Organism |
---|---|
genes TPH1 and TPH2, expression analysis, overview, expression of wild-type TPH1 and TPH2 in rat PC-12 cells, in vitro transcription and translation using reticulocyte lysate, the TPH2 extended N-terminal domain plays a role in modulating the enzyme expression, expression of mutant HA-TPH2-(1-41)-TPH1 in HEK-293 amd PC-12 cells, the expression level of the chimeric protein is significantly decreased compared with TPH1 in both cell lines and is more similar to that of TPH2, the N-terminal regulatory determinant is transferable, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a chimeric protein HA-TPH2-(1-41)-TPH1 composed of the first 41 amino acids of TPH2 appended to the N terminus of TPH1, the expression level of the chimeric protein is significantly decreased compared with TPH1 in HEK-293 and PC-12 cell lines and is more similar to that of TPH2 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | differences in the regulation of isozyme TPH2 versus isozyme TPH1, overview | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IWU9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | differences in the regulation of isozyme TPH2 versus isozyme TPH1, overview | Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH2 | - |
Homo sapiens |
tryptophan hydroxylase 2 | - |
Homo sapiens |