Cloned (Comment) | Organism |
---|---|
TPH1 and TPH2 genotyping | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | G703T and C218A are naturally occuring polymorphisms, genotyping of TPH1 and TPH2 in correlation to alcohol abuse, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | the enzyme is rate limiting in serotonin biosynthesis and important in serotonergic neurotransmission, overview | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
additional information | Homo sapiens | alcohol consumption may influence TPH1 and TPH2 expression and regulation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P17752 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
midbrain | - |
Homo sapiens | - |
neuron | serotonergic | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | the enzyme is rate limiting in serotonin biosynthesis and important in serotonergic neurotransmission, overview | Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
additional information | alcohol consumption may influence TPH1 and TPH2 expression and regulation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH1 | - |
Homo sapiens |
TPH2 | - |
Homo sapiens |
tryptophan hydroxylase 1 | - |
Homo sapiens |
tryptophan hydroxylase 2 | - |
Homo sapiens |