Literature summary for 1.14.16.4 extracted from

Hong, K.W.; Sugawara, Y.; Hasegawa, H.; Hayasaka, I.; Hashimoto, R.; Ito, S.; Inoue-Murayama, M.
A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats (2007), Neurosci. Lett., 412, 195-200.

Search for more literature for 1.14.16.4

Cloned(Commentary)

Cloned (Comment)	Organism
expression in HeLa cells	Homo sapiens
expression in HeLa cells	Rattus norvegicus
TPH2, DNA and amino acid sequence determination and analysis, genotyping, expression of mutant Q468R in HeLa cells, overview	Pan troglodytes

Protein Variants

Protein Variants	Comment	Organism
C164A/G170A	mutations represent differences between the human and chimpanzee enzyme, activity similar to wild-type	Homo sapiens
C164A/G170A/Q468R	mutations represent differences between the human and chimpanzee enzyme and a polymorphism at position 468 present in chimpanzees but not in humans. 1.4fold activity compared to wild-type	Homo sapiens
Q486R	determination of a naturally occuring single nucleotide polymorphism at the exon 11 coding region that resulted in amino acid substitutions in the C-terminal domain, determination of allele frequency, the mutation is a gain -of-function mutation leading to 20% increased activity, comparison to rat and human TPH2s, overview	Pan troglodytes

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	Pan troglodytes	TPH2 is a rate-limiting enzyme of neuronal serotonin biosynthesis	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Organism

Organism	UniProt	Comment	Textmining
Callithrix jacchus	-	-	-
Cephalopachus bancanus	-	-	-
Gorilla gorilla	-	-	-
Homo sapiens	-	-	-
Hylobates agilis	-	-	-
Macaca fuscata	-	-	-
Mandrillus sphinx	-	-	-
Otolemur crassicaudatus	-	-	-
Pan troglodytes	-	-	-
Pongo pygmaeus	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cell culture	-	Homo sapiens	-
cell culture	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	-	Homo sapiens	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2	1.3fold activity compared to the human tryptophan hydroxylase 2	Rattus norvegicus	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + tetrahydrobiopterin + O2	-	Pan troglodytes	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + tetrahydrobiopterin + O2	TPH2 is a rate-limiting enzyme of neuronal serotonin biosynthesis	Pan troglodytes	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Synonyms

Synonyms	Comment	Organism
TPH2	-	Homo sapiens
TPH2	-	Rattus norvegicus
TPH2	-	Macaca fuscata
TPH2	-	Pan troglodytes
TPH2	-	Callithrix jacchus
TPH2	-	Pongo pygmaeus
TPH2	-	Cephalopachus bancanus
TPH2	-	Otolemur crassicaudatus
TPH2	-	Gorilla gorilla
TPH2	-	Hylobates agilis
TPH2	-	Mandrillus sphinx
tryptophan hydroxylase 2	-	Homo sapiens
tryptophan hydroxylase 2	-	Rattus norvegicus
tryptophan hydroxylase 2	-	Macaca fuscata
tryptophan hydroxylase 2	-	Pan troglodytes
tryptophan hydroxylase 2	-	Callithrix jacchus
tryptophan hydroxylase 2	-	Pongo pygmaeus
tryptophan hydroxylase 2	-	Cephalopachus bancanus
tryptophan hydroxylase 2	-	Otolemur crassicaudatus
tryptophan hydroxylase 2	-	Gorilla gorilla
tryptophan hydroxylase 2	-	Hylobates agilis
tryptophan hydroxylase 2	-	Mandrillus sphinx

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Release 2023.1 (January 2023)