Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.16.4 extracted from

  • McKinney, J.; Knappskog, P.M.; Haavik, J.
    Different properties of the central and peripheral forms of human tryptophan hydroxylase (2005), J. Neurochem., 92, 311-320.
    View publication on PubMed
Search for more literature for 1.14.16.4

Cloned(Commentary)

Cloned (Comment) Organism
TPH1, expression in Escherichia coli Homo sapiens
TPH2, expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin TPH2, substrate inhibition Homo sapiens
L-tryptophan TPH2, substrate inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0106
-
 L-tryptophan TPH1 fusion protein with maltose-binding protein Homo sapiens
0.0128
-
 (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin TPH2 fusion protein with maltose-binding protein Homo sapiens
0.0131
-
 L-tryptophan TPH2, in vitro transcription and translation product Homo sapiens
0.0202
-
 (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin TPH2 Homo sapiens
0.0228
-
 L-tryptophan TPH1 Homo sapiens
0.027
-
 (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin TPH1 fusion protein with maltose-binding protein Homo sapiens
0.039
-
 (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin TPH1 Homo sapiens
0.0403
-
 L-tryptophan TPH2 Homo sapiens
0.0434
-
 L-tryptophan TPH2 fusion protein with maltose-binding protein Homo sapiens
0.111
-
 L-tryptophan TPH1. in vitro transcription and translation product Homo sapiens
0.146
-
 (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin TPH1, in vitro transcription and translation product Homo sapiens
0.281
-
 (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin TPH2, in vitro transcription and translation product Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58500
-
 4 * 58500, TPH1 Homo sapiens
68500
-
 4 * 68500, TPH2 Homo sapiens
234000
-
 TPH1, gel filtration Homo sapiens
274000
-
 TPH2, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydropteridine + O2 Homo sapiens rate-limiting step in biosynthesis of serotonin in brain 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein TPH1 is phosphorylated by cAMP-dependent protein kinase A Homo sapiens
phosphoprotein TPH2 is phosphorylated by cAMP-dependent protein kinase A Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin + O2
-
 Homo sapiens 5-hydroxy-L-tryptophan + ?
-
 ?
L-tryptophan + tetrahydropteridine + O2 rate-limiting step in biosynthesis of serotonin in brain Homo sapiens 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?

Subunits

Subunits Comment Organism
tetramer 4 * 58500, TPH1 Homo sapiens
tetramer 4 * 68500, TPH2 Homo sapiens

Synonyms

Synonyms Comment Organism
TPH1
-
 Homo sapiens
TPH2
-
 Homo sapiens