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Literature summary for 1.14.16.4 extracted from

  • Walther, D.J.; Bader, M.
    A unique central tryptophan hydroxylase isoform (2003), Biochem. Pharmacol., 66, 1673-1680.
    View publication on PubMed

Application

Application Comment Organism
medicine the two distinct serotonin systems in the brain (TPH2) and in the periphery (TPH1) can be targeted independently by pharmacological agents and new therapeutical options are available for psychiatric diseases on one side and disorders of haemostasis and the immune system on the other side Homo sapiens
medicine TPH2 is a good candidate gene for 5-hydroxytryptophan related psychiatric diseases such as bipolar affective disorders. The two distinnct serotonin systems in the brain (TPH2) and in the periphery (TPH1) can be targeted independently by pharmacological agents and new therapeutical options are available for psychiatric diseases on one side and disorders of haemostasis and the immune system on the other side Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain TPH2 Homo sapiens
-
gut TPH1 Homo sapiens
-
pineal gland TPH1 Homo sapiens
-
spleen TPH1 Homo sapiens
-
thymus TPH1 Homo sapiens
-

Synonyms

Synonyms Comment Organism
TPH1
-
Homo sapiens
TPH2
-
Homo sapiens