Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.16.4 extracted from

  • Park, D.H.; Stone, D.M.; Kim, K.S.; Joh, T.H.
    Characterization of recombinant mouse tryptophan hydroxylase expressed in Escherichia coli (1994), Mol. Cell. Neurosci., 5, 87-93.
    View publication on PubMed
Search for more literature for 1.14.16.4

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
serotonin 1 mM, 7.5% inhibition, 10 mM, 70% inhibition Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0752
-
 2-amino-4-hydroxy-6-methyltetrahydropteridine
-
 Mus musculus
0.355
-
 L-tryptophan
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.367
-
-
 Rattus norvegicus
0.374
-
-
 Rattus norvegicus
0.434
-
 recombinant enzyme, activity in cell extracts Mus musculus
5.28
-
-
 Mus musculus

Storage Stability

Storage Stability Organism
-20°C, 10% glycerol, 0.05 mM EDTA, 0.06% Tween 20, 28 d, 69% loss of activity Mus musculus
4°C, 10% glycerol, 0.05 mM EDTA, 0.06% Tween 20, 28 d, 34% loss of activity Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + 2-amino-4-hydroxy-6-methyl-tetrahydropteridine + O2
-
 Mus musculus ?
-
 r