Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | chronic administration of the antipsychotic drug haloperidol causes a significant increase in locomotor activity and lower levels of tyrosine hydroxylase immunoreactivity in the caudate putamen of the striatum, another drug, quetiapine, does not cause effects to the same extent and protects the cell and tyrosine hydoxylase against oxidative stress-induced damage, overview | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | Rattus norvegicus | - |
3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Sprague-Dawley albino rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | substantia nigra and ventral tegmental areas | Rattus norvegicus | - |
caudate putamen | - |
Rattus norvegicus | - |
corpus striatum | - |
Rattus norvegicus | - |
substantia nigra | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | - |
Rattus norvegicus |