Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | KCl induces the enzyme through activation of protein kinase C and protein kinase A, inhibition of induction by inhibitors H89 and SQ22536, but not by inhibitor PP2, overview | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | Rattus norvegicus | - |
3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
additional information | Rattus norvegicus | neuronal activity, modulated e.g. by KCl, mediates changes in TH expression, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
pregnant Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
enteric nervous system | - |
Rattus norvegicus | - |
neuron | olfactory and sensory neurons, cholinergic and adrenergic pathways modulate the proprotion of tyrosine hydroxylase-immunoreactive neurons, KCl induces the number of positive TH-IR neurons involving L-type Ca2+ channels, overview | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
additional information | neuronal activity, modulated e.g. by KCl, mediates changes in TH expression, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | - |
Rattus norvegicus |