Literature summary for 1.14.16.2 extracted from

Fukuda, T.; Ishii, K.; Nanmoku, T.; Isobe, K.; Kawakami, Y.; Takekoshi, K.
5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside stimulates tyrosine hydroxylase activity and catecholamine secretion by activation of AMP-activated protein kinase in PC12 cells (2007), J. Neuroendocrinol., 19, 621-631.

Search for more literature for 1.14.16.2

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside activates the enzyme via AMP-activated protein kinase activation, AMP-activated protein kinase activates the enzyme by reversible phosphorylation at Ser19, Ser31, and Ser40	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	PD-098059, compound C, i.e. 6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, and 5'-amino-5'-dAdo inhibit the activation of the enzyme by AMP-activated protein kinase, PD-098059 specifically inhibits phosphorylation at Ser31 without affecting phosphorylation at Ser19 and Ser40	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	Rattus norvegicus	-	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	AMP-activated protein kinase activates the enzyme by reversible phosphorylation at Ser19, Ser31, and Ser40, activated by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside and inhibited by PD-098059, compound C and 5'-amino-5'-dAdo, PD-098059 specifically inhibits phosphorylation at Ser31 without affecting phosphorylation at Ser19 and Ser40	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
PC-12 cell	a pheochromocytoma cell line	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	determination of catecholamine secretion	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	-	Rattus norvegicus	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Synonyms

Synonyms	Comment	Organism
tyrosine hydroxylase	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6	-	assay at	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
tetrahydrobiopterin	-	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)