Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis of wild-type enzyme and polymorphic genetic variants, expression in human chromaffin cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | detection of single nucleotide polymorphisms in the local genomic region, systematic polymorphism discovery at the TH locus and analysis for contributions to sympathetic function and blood pressure, i.e. 4 common TH promoter polymorphisms C-824T, G-801C, A-581G, and G-494A, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | Homo sapiens | tyrosine hydroxylase is the rate-limiting enzyme in catecholamine biosynthesis | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Homo sapiens | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | tyrosine hydroxylase is the rate-limiting enzyme in catecholamine biosynthesis | Homo sapiens | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | - |
Homo sapiens |