Application | Comment | Organism |
---|---|---|
analysis | the enzyme is useful for determination of neuronal loss after brain treatment with neurotoxic compounds, overview | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | Rattus norvegicus | tyrosine hydroxylase is involved in dopamine biosynthesis and the rat nigrostriatal pathway, overview | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | of wild-type and striatal 6-hydroxydopamine lesioned rats | Rattus norvegicus | - |
corpus striatum | - |
Rattus norvegicus | - |
additional information | immunohistochemic analysis of enzyme content in neurons of wild-type and striatal 6-hydroxydopamine lesioned rats, overview | Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | tyrosine hydroxylase is involved in dopamine biosynthesis and the rat nigrostriatal pathway, overview | Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | - |
Rattus norvegicus |