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Literature summary for 1.14.16.2 extracted from

  • Gomes, M.Z.; Raisman-Vozari, R.; Del Bel, E.A.
    A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway (2008), Brain Res., 1203, 160-169.
    View publication on PubMed

Application

Application Comment Organism
analysis the enzyme is useful for determination of neuronal loss after brain treatment with neurotoxic compounds, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 Rattus norvegicus tyrosine hydroxylase is involved in dopamine biosynthesis and the rat nigrostriatal pathway, overview 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain of wild-type and striatal 6-hydroxydopamine lesioned rats Rattus norvegicus
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corpus striatum
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Rattus norvegicus
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additional information immunohistochemic analysis of enzyme content in neurons of wild-type and striatal 6-hydroxydopamine lesioned rats, overview Rattus norvegicus
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neuron
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2
-
Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
?
L-tyrosine + tetrahydrobiopterin + O2 tyrosine hydroxylase is involved in dopamine biosynthesis and the rat nigrostriatal pathway, overview Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
?

Cofactor

Cofactor Comment Organism Structure
tetrahydrobiopterin
-
Rattus norvegicus